© 2018

Muse Cells

Endogenous Reparative Pluripotent Stem Cells

  • Mari Dezawa


  • Presents up-to-date knowledge on Muse cells, newly recognized pluripotent stem cells that will be vital for next-generation medical care

  • Covers all aspects from molecular and cellular properties to differentiation ability, tissue repair properties, and the diverse potential clinical applications of Muse cells

  • Provides a precise protocol for collection of Muse cells


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1103)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Shohei Wakao, Yoshihiro Kushida, Mari Dezawa
    Pages 13-41
  3. Yoshihiro Kushida, Shohei Wakao, Mari Dezawa
    Pages 43-68
  4. Kazuki Tatsumi, Yoshihiro Kushida, Shohei Wakao, Yasumasa Kuroda, Mari Dezawa
    Pages 69-101
  5. Tiziana Squillaro, Nicola Alessio, Giovanni Di Bernardo, Servet Özcan, Gianfranco Peluso, Umberto Galderisi
    Pages 103-113
  6. Marcelo Javier Perone, María Laura Gimeno, Florencia Fuertes
    Pages 115-129
  7. Shinya Minatoguchi, Atsushi Mikami, Toshiki Tanaka, Shingo Minatoguchi, Yoshihisa Yamada
    Pages 153-166
  8. Kuniyasu Niizuma, Cesar V. Borlongan, Teiji Tominaga
    Pages 167-186
  9. Satoshi Kuroda, Masaki Koh, Emiko Hori, Yumiko Hayakawa, Takuya Akai
    Pages 187-198
  10. Nao Uchida, Naonori Kumagai, Yoshiaki Kondo
    Pages 199-218
  11. Satoshi S. Nishizuka, Yuji Suzuki, Hirokatsu Katagiri, Yasuhiro Takikawa
    Pages 219-241
  12. Taketo Nishina, Kyoko Tomita Hoshikawa, Yoshiyuki Ueno
    Pages 243-253
  13. Takeshi Yamauchi, Kenshi Yamasaki, Kenichiro Tsuchiyama, Setsuya Aiba
    Pages 255-271
  14. Katsuhiro Hosoyama, Yoshikatsu Saiki
    Pages 273-291
  15. Hiroshi Yabuki, Tatsuaki Watanabe, Hisashi Oishi, Masato Katahira, Masahiko Kanehira, Yoshinori Okada
    Pages 293-303
  16. Mari Dezawa
    Pages 305-307
  17. Wise Young
    Pages 309-315
  18. Shohei Wakao, Yoshihiro Kushida, Mari Dezawa
    Pages C1-C1

About this book


This book provides the first comprehensive account of multilineage-differentiating stress-enduring (Muse) cells, a pluripotent and non-tumorigenic subpopulation of mesenchymal stem cells (MSCs) that have the ability to detect damage signals, migrate to damaged sites, and spontaneously differentiate into cells compatible with the affected tissue, thereby enabling repair of all tissue types. The coverage encompasses everything from the basic properties of Muse cells to their tissue repair effects and potential clinical applications—for example, in acute myocardial infarction, stroke, skin injuries and ulcers, renal failure, and liver disease. An important technical chapter provides a practical and precise protocol for the isolation of Muse cells, which will enable readers to use Muse cells in their own research. In offering fascinating insights into the strategic organization of the body’s reparative function and explaining how full utilization of Muse cells may significantly enhance the effectiveness of MSC treatment, the book will be of high value for Ph.D. students, postdocs, basic researchers, clinical doctors, and industrial developers.


Mesenchymal stem cells Non-tumorigenicity Pluripotent stem cells Regenerative medicine Tissue engineering Tissue homeostasis

Editors and affiliations

  • Mari Dezawa
    • 1
  1. 1.Tohoku University Graduate School of MedicineSendaiJapan

About the editors

Mari Dezawa, M.D., Ph.D., is professor and chairperson at the Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine (Japan). She has contributed to regenerative medicine by discovering non-tumorigenic reparative pluripotent stem cells, multilineage-differentiating stress-enduring (Muse) cells that naturally reside in the living body. Dr. Dezawa graduated from Chiba University School of Medicine in 1989 and gained her Ph.D. from the same university in 1995. In 2000 she joined Yokohama City University, where she started mesenchymal stem cell (MSC) research. After moving to Kyoto University Graduate School of Medicine as associate professor in 2003, she discovered methods to induce neurons and skeletal muscle cells from human MSCs by combining gene introduction and cytokine stimulation. In 2008, she became professor and chair of the Department of Stem Cell Biology and Histology at Tohoku University Graduate School of Medicine. She subsequently has published a number of articles in leading journals on Muse cells and their reparative functions in animal disease models. Dr. Dezawa is the author of more than 120 original articles in international journals and serves as an editorial board member of several international journals. She is a fellow of the National Academy of Inventors, USA.

Bibliographic information

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