© 2017


From Structure and Function to Physiological and Pathological Roles

  • Tomoaki Shirao
  • Yuko Sekino
  • Offers the first comprehensive review of drebrin from its molecular structure and function to the physiological and pathological roles edited by the discoverer of drebrin

  • Presents a multidisciplinary review of drebrin including that of neuroscience, cancer science, immunology, and cell biology in various tissues

  • Provides the most up-to-date knowledge and intriguing hypotheses related to drebrin and drebrin-decorated F-actin by authoritative original authors of key papers


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1006)

Table of contents

  1. Front Matter
    Pages i-xii
  2. History of Drebrin Discovery as an General Introduction

    1. Front Matter
      Pages 1-1
    2. Tomoaki Shirao, Yuko Sekino
      Pages 3-22
  3. Basic Information About Drebrin

    1. Front Matter
      Pages 23-23
    2. Phillip R. Gordon-Weeks
      Pages 49-60
    3. Kensuke Hayashi
      Pages 83-101
  4. Drebrin in Nervous System

    1. Front Matter
      Pages 103-103
    2. Tomoaki Shirao, Noriko Koganezawa, Hiroyuki Yamazaki, Kenji Hanamura, Kazuyuki Imamura
      Pages 105-118
    3. Hideto Takahashi, Yusuke Naito
      Pages 157-181
    4. Yuko Sekino, Noriko Koganezawa, Toshiyuki Mizui, Tomoaki Shirao
      Pages 183-201
    5. Yuta Ishizuka, Kenji Hanamura
      Pages 203-223
    6. Irina V. Majoul, Justus S. Ernesti, Eugenia V. Butkevich, Rainer Duden
      Pages 225-247
    7. Hiroyuki Yamazaki, Tomoaki Shirao
      Pages 249-268
  5. Drebrin in Non-Nervous System

    1. Front Matter
      Pages 269-269
    2. Vera Rocha-Perugini, Mónica Gordon-Alonso, Francisco Sánchez-Madrid
      Pages 271-280

About this book


This book is the first comprehensive review of drebrin, which plays pivotal roles in various cellular events, via forming unique actin cytoskeletons, including synapse formation and in synaptic function. Particularly the loss of drebrin from dendritic spines is used as a marker of dementia in neurological disorders such as Alzheimer’s disease. Since drebrin was first identified by our group in 1985, many studies of drebrin have been done in various fields, including not only molecular biology, biophysics, cell biology, neuroscience, clinical studies, spermatogenesis, immunology, and cancer metastasis, but others as well. The structure of this book facilitates the understanding of the whole picture of studies on drebrin. The volume begins with a general introduction to drebrin, and then the chapters in the second part provide the basic knowledge for further understanding. The third part examines its function in the nervous system, and the fourth part discusses its function in the non-nervous system. This work will appeal to researchers who are interested in cytoskeletal dynamics at membrane-cytoskeletal interface as well as the number of them who use drebrin as a tool, such as a marker of synaptic function or a disease marker. This volume is kept as concise as possible in order to be understood by readers in diverse scientific disciplines.


Actin filament Cell migration Process formation Synapse formation Synaptic plasticity Adherens junctions GAP junction Cancer Metastasis Alzheimer’s disease

Editors and affiliations

  • Tomoaki Shirao
    • 1
  • Yuko Sekino
    • 2
  1. 1.Department of Neurobiology and BehaviorGunma University Graduate School of MedicineMaebashiJapan
  2. 2.Laboratory of Chemical PharmacologyGraduate School of Pharmaceutical SciencesThe University of TokyoJapan

About the editors

Tomoaki Shirao, MD, PhD
Department of Neurobiology and Behavior
Gunma University Graduate School of Medicine
Gunma, Japan

Yuko Sekino, PhD
Division of Pharmacology
National Institute of Health Sciences
Tokyo, Japan

Bibliographic information

  • Book Title Drebrin
  • Book Subtitle From Structure and Function to Physiological and Pathological Roles
  • Editors Tomoaki Shirao
    Yuko Sekino
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer Japan KK 2017
  • Publisher Name Springer, Tokyo
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-4-431-56548-2
  • Softcover ISBN 978-4-431-56817-9
  • eBook ISBN 978-4-431-56550-5
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XII, 401
  • Number of Illustrations 29 b/w illustrations, 82 illustrations in colour
  • Topics Neurochemistry
    Biochemistry, general
    Cell Biology
  • Buy this book on publisher's site
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