Pathogenesis of Idiopathic Scoliosis

  • Masafumi Machida
  • Stuart L. Weinstein
  • Jean Dubousset

Table of contents

  1. Front Matter
    Pages i-ix
  2. Cameron B. Barton, Stuart L. Weinstein
    Pages 27-50
  3. Anas M. Khanshour, Carol A. Wise
    Pages 51-74
  4. Wafa Skalli, Claudio Vergari
    Pages 75-97
  5. Jack C. Y. Cheng, Wayne Y. W. Lee, Elisa M. S. Tam, T. P. Lam
    Pages 125-155
  6. Masafumi Machida
    Pages 157-188

About this book


This book provides comprehensive coverage of current topics in idiopathic scoliosis (IS). A three-dimensional deformity of the spine, the condition is characterized by lateral curvature combined with vertebral rotation. The primary lesion, however, lies in the median sagittal plane, taking the form of a lordosis. Although the clinical manifestations of scoliosis have been well documented, its cause and pathogenesis have not yet been determined. Research into what causes IS has focused on the structural elements of the spine, spinal musculature, collagenous structures, the endocrine system, the central nervous system, and genetics. Results of these studies have brought about a new perception of IS epiphenomena, but the main cause of IS remains unknown. Recently, several investigators have produced new hypotheses regarding the cause of IS using the developing techniques of genetics, biochemistry, and neurology. This book is a review of the various causative factors thus far proposed for IS and an introduction to the directions in which research is heading to determine the primary cause of IS.


Idiopathic Scoliosis Pathogenesis Study Spinal Deformity Central nervous system Genetics research

Editors and affiliations

  • Masafumi Machida
    • 1
  • Stuart L. Weinstein
    • 2
  • Jean Dubousset
    • 3
  1. 1.Department of Spine and Spinal Cord SurgeryYokohama Brain and Spine CenterYokohamaJapan
  2. 2.University of IowaIowaUSA
  3. 3.Academie Nationale de MedecineParisFrance

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