Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds

  • Kenji Sugibayashi

Table of contents

  1. Front Matter
    Pages i-x
  2. General Introduction

    1. Front Matter
      Pages 1-1
    2. Kenji Sugibayashi
      Pages 13-53
    3. Kenji Sugibayashi
      Pages 55-65
    4. Tomomi Hatanaka
      Pages 67-76
    5. Eddy Yusuf, Mohd. Shukri Ab Yajid
      Pages 101-107
  3. Basic Formulations Applied to Skin

    1. Front Matter
      Pages 109-109
    2. Taki Koffi Alphonse
      Pages 111-120
    3. Yasunari Michinaka
      Pages 121-135
    4. Mami Yokota, Yoshihiro Tokudome
      Pages 137-142
    5. Maria Lapteva, Yogeshvar N. Kalia
      Pages 153-161
  4. Skin Penetration Enhancement

    1. Front Matter
      Pages 163-163
    2. Mayank Singhal, Yogeshvar N. Kalia
      Pages 165-182
    3. Mitsuhiro Shikida
      Pages 183-194
    4. Kenji Sugibayashi
      Pages 205-224
    5. Momoko Kitaoka, Masahiro Goto
      Pages 225-232
    6. Yuya Egawa, Toshinobu Seki
      Pages 233-239
    7. Liang Fang, Wenting Song
      Pages 241-248
  5. Selection of Topically Applied Chemical Candidates

    1. Front Matter
      Pages 249-249
    2. Hiroshi Ishii
      Pages 263-271
    3. Sachiko Hirobe, Sayami Ito, Naoki Okada
      Pages 281-288
  6. Safety Assessment of Topically Applied Compounds

    1. Front Matter
      Pages 289-289
    2. Katsuhiko Yoshizawa, Yuichi Kinoshita, Akiko Takenouchi, Airo Tsubura
      Pages 291-296
    3. Hajime Kojima
      Pages 297-304
    4. Xiaowen Liang, Haolu Wang, Xin Liu, Jeffrey Grice, Zhi Ping Xu, Michael S. Roberts
      Pages 313-322
  7. Experimental Methods of Skin Permeation

    1. Front Matter
      Pages 323-323
    2. Makiko Fujii
      Pages 325-333
    3. Tetsuya Watanabe
      Pages 335-343
    4. Michiya Matsusaki, Kumiko Fujimoto, Yuji Shirakata, Satoshi Hirakawa, Koji Hashimoto, Mitsuru Akashi
      Pages 345-362
    5. Hiromi Baba, Jun-ichi Takahara, Fumiyoshi Yamashita
      Pages 363-376
    6. Toshinobu Seki, Ryotaro Miki
      Pages 377-384
    7. Bálint Sinkó, Krisztina Takács-Novák
      Pages 391-397
    8. Hiroaki Todo, Fadli Mohd
      Pages 399-409
  8. Comments from Medical Doctors and Pharmacists

    1. Front Matter
      Pages 411-411
    2. Tomonobu Uchino
      Pages 423-428

About this book


This book reviews skin permeation and disposition of chemical compounds. Skin is utilized as an administration site for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Their usefulness is closely related to the permeation and disposition of entrapped active ingredients through and into the skin. Skin permeation, disposition, and metabolism of chemicals are first summarized in the general introduction. Then primary topical formulations are explained in the second part, “Basic Formulations Applied to Skin”. The explanation for the active compounds and formulations are of the most important parts required to fabricate these formulations. Skin absorption of chemicals is generally much lower than oral and the other mucosal absorptions, so that skin-penetration enhancement is a key issue to have good formulations topically applied. Part 3 presents “Skin Penetration Enhancement”. In addition, Part 4, “Selection of Topically Applied Chemical Candidates”, deals with selection methods of topically applied ingredients for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Parts 5 and 6, “Safety Assessment of Topically Applied Compounds“ and “Experimental Methods of Skin Permeation“, respectively, show safety issues and experimental methods for topical formulations. The final part consists of comments on therapeutic and cosmetic formulations by medical doctors and pharmacists. Their comments are especially helpful for pharmaceutical and cosmetic researchers who study dermatopharmacokinetics and topical formulations.

This volume is particularly useful for those working in R&D, graduate students, and educators in the area of pharmaceutics, cosmetic sciences, dermatological sciences, pharmacology, toxicology, biopharmacy, pharmacokinetics, physical pharmacy, chemical engineering, and related fields.


Skin penetration Percutaneous absorption Skin disposition Transdermal drug delivery systems Topical drug formulations Cosmetics Skin penetration enhancement Safety assessment of topical formulations

Editors and affiliations

  • Kenji Sugibayashi
    • 1
  1. 1.President, Josai International UniversityToganeJapan

Bibliographic information

Industry Sectors
Health & Hospitals
Consumer Packaged Goods