Hepatitis C Virus I

Cellular and Molecular Virology

  • Tatsuo Miyamura
  • Stanley M. Lemon
  • Christopher M. Walker
  • Takaji Wakita

Table of contents

  1. Front Matter
    Pages i-ix
  2. Hepatitis C Virus

    1. Front Matter
      Pages 1-1
    2. Michael Houghton
      Pages 3-14
    3. Tadasu Shin-I, Masaya Sugiyama, Masashi Mizokami
      Pages 15-29
    4. Joseph Marcotrigiano, Maria Teresa Catanese
      Pages 31-64
  3. The Viral Life Cycle

    1. Front Matter
      Pages 65-65
    2. Rajiv G. Tawar, Catherine Schuster, Thomas F. Baumert
      Pages 81-103
    3. Kohji Moriishi, Yoshiharu Matsuura
      Pages 105-127
    4. Tetsuro Suzuki, Ryosuke Suzuki
      Pages 129-148
    5. Inés Romero-Brey, Volker Lohmann
      Pages 149-196
    6. Ana Shulla, Glenn Randall
      Pages 197-233
    7. Daisuke Yamane, Stanley M. Lemon
      Pages 235-253
    8. Takayuki Hishiki, Yuko Shimizu, Saneyuki Ujino, Hironori Nishitsuji, Kunitada Shimotohno
      Pages 255-272
  4. Immune Recognition and Pathogenesis

    1. Front Matter
      Pages 273-273
    2. Markus von Schaewen, Jenna M. Gaska, Alexander Ploss
      Pages 275-297
    3. Zhen-Yong Keck, Thomas R. Fuerst, Roy A. Mariuzza, Steven K. H. Foung
      Pages 331-357
  5. Back Matter
    Pages 359-362

About this book


This volume is composed of chapters that review important fundamental aspects of HCV biology and disease pathogenesis including, for example, the discovery and identification of the HCV genome, early virus-cell interactions including identification of various cellular receptors, HCV gene expression studied using the HCV replicon system, identification and characterization of HCV structural- and non-structural HCV proteins, HCV replication in cultured cells, and host factors involved in viral replication. This volume also contains chapters dealing with immunity to HCV infection and pathogenesis. This is particularly important in understanding hepatitis C because HCV infection alone is not cell lytic. Mechanisms underlying the persistent nature of HCV infection are also discussed in these chapters. Many of the authors published articles that were listed among the “top 10 papers” published in the 24 years since HCV was discovered in 1989. Their citations are above 1,000 (Web of Science). The authors describe the background and significance of their contributions to the field in the context of findings from other research groups”.


HCV Immunity Liver Pathogen Replication Strategy Virology

Editors and affiliations

  • Tatsuo Miyamura
    • 1
  • Stanley M. Lemon
    • 2
  • Christopher M. Walker
    • 3
  • Takaji Wakita
    • 4
  1. 1.National Institute of Infectious DiseasesTokyoJapan
  2. 2.Departments of Medicine and Microbiology & Immunology The University of North CarolinaChapel HillUSA
  3. 3.Center for Vaccines and ImmunityThe Research Institute at Nationwide Children's Hospital ColumbusUSA
  4. 4.National Institute of Infectious DiseasesTokyoJapan

Bibliographic information

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