Development and Disease

  • Kazuo Emoto
  • Rachel Wong
  • Eric Huang
  • Casper Hoogenraad

Table of contents

  1. Front Matter
    Pages i-vii
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Kazuo Emoto, Rachel Wong, Eric Huang, Casper Hoogenraad
      Pages 3-6
  3. Basic Biology of Dendrites

    1. Front Matter
      Pages 7-7
    2. Amr Abou Elezz, Rimante Minkeviciene, Pirta Hotulainen
      Pages 9-29
    3. Elena Tortosa, Lukas C. Kapitein, Casper C. Hoogenraad
      Pages 31-75
    4. Sujoy Bera, Gonca Bayraktar, Katarzyna M. Grochowska, Michelle Melgarejo da Rosa, Michael R. Kreutz
      Pages 111-124
    5. Nuno Maçarico da Costa
      Pages 125-137
  4. Patterning Dendritic Architecture of Neurons and Their Populations

    1. Front Matter
      Pages 155-155
    2. Peter Soba
      Pages 157-179
    3. Jay Z. Parrish
      Pages 181-211
    4. Peter G. Fuerst
      Pages 213-244
    5. Yuan Wang, Edwin W. Rubel
      Pages 245-270
  5. Cellular and Molecular Control of Dendrite Development and Maintenance

    1. Front Matter
      Pages 271-271
    2. Kazuya Togashi, Hiroyuki Koizumi, Takahiro Kanamori, Kazuo Emoto
      Pages 273-294
    3. Hollis T. Cline
      Pages 295-315
    4. Sara Marie Katrancha, Anthony J. Koleske
      Pages 317-355
  6. Synapse Formation Onto Dendrites

    1. Front Matter
      Pages 357-357
    2. Hirohide Iwasaki, Shinji Tanaka, Shigeo Okabe
      Pages 359-385
    3. Arthur Bikbaev, Maël Duménieu, Jeffrey Lopez-Rojas, Martin Heine
      Pages 387-424
    4. Peter Chipman, Yukiko Goda
      Pages 425-465
    5. Katherine L. Villa, Elly Nedivi
      Pages 467-487
    6. Florence D. D’Orazi, Takeshi Yoshimatsu
      Pages 489-522
  7. Dendrites in Disease

    1. Front Matter
      Pages 523-523
    2. Verónica Martínez-Cerdeño, Izumi Maezawa, Lee-Way Jin
      Pages 525-543
    3. Sebum Lee, Yulei Shang, Eric J. Huang
      Pages 545-579
    4. Luca Della Santina, Yvonne Ou
      Pages 581-597
  8. Back Matter
    Pages 599-608

About this book


Studies in human patients and animal models of disease suggest a strong correlation between defects in dendrite development and common neurological disorders such as autism. Much of this book is thus dedicated toward highlighting recent advances in our understanding of the cellular and molecular mechanisms that regulate the development and maintenance of dendrites, a crucial component of neurons. The book begins by presenting the current state of knowledge on the building blocks or cell biology of dendrites. Mechanisms that sculpt the stereotypic architecture of dendritic arbors and shape their connectivity are also discussed, along with recent work describing how dendritic organization and connectivity are perturbed in disease. A unique aspect of the book is its exploration of diverse neuronal cell types across vertebrates and invertebrates, allowing a comparison of mechanisms across distinct circuits and species. The book comprises six parts, which cover the major advances in the field: Part 1, Introduction; Part 2, Basic Biology of Dendrites; Part 3, Patterning Dendritic Architecture of Neurons and Their Populations; Part 4, Cellular and Molecular Control of Dendrite Development and Maintenance; Part 5, Synapse Formation onto Dendrites; and Part 6, Dendrites in Disease. The book offers an excellent point of entry for students interested in neuroscience, as well as for clinicians.


Dendrite Axon Synapses Neuronal wiring Invertebrate brain Vertebrate nervous system

Editors and affiliations

  • Kazuo Emoto
    • 1
  • Rachel Wong
    • 2
  • Eric Huang
    • 3
  • Casper Hoogenraad
    • 4
  1. 1.Graduate School of ScienceThe University of TokyoTokyoJapan
  2. 2.Department of Biological StructureUniversity of WashingtonSeattleUSA
  3. 3.Department of PathologyUniversity of California San FranciscoSan FranciscoUSA
  4. 4.Faculty of ScienceUtrecht UniversityUtrechtThe Netherlands

Bibliographic information

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