© 2016

The Cadherin Superfamily

Key Regulators of Animal Development and Physiology

  • Shintaro T. Suzuki
  • Shinji Hirano
  • Presents an overview of cadherin research from cellular and developmental biology to medical science

  • Offers a concise guide for a wide range of readers, from beginners to experts in the field

  • Inspires future studies by providing contradictory results, unsolved questions, and the authors’ working hypotheses or future directions

  • Provides a list for quick reference to cadherins in human diseases


Table of contents

  1. Front Matter
    Pages i-xii
  2. Overview

    1. Front Matter
      Pages 1-1
    2. Shintaro T. Suzuki, Shinji Hirano
      Pages 3-11
    3. Paco Hulpiau, Ismail Sahin Gul, Frans van Roy
      Pages 13-37
  3. Classical Cadherins

    1. Front Matter
      Pages 39-39
    2. Barry M. Gumbiner
      Pages 41-69
    3. Jiongyi Tan, Blair W. Benham-Pyle, William I. Weis, W. James Nelson
      Pages 93-114
    4. Takeshi Fujiwara, Akira Mizoguchi, Yoshimi Takai
      Pages 115-156
  4. Atypical Cadherins

    1. Front Matter
      Pages 157-157
    2. Martyn Chidgey, David Garrod
      Pages 159-193
    3. Kar Men Mah, Joshua A. Weiner
      Pages 195-221
    4. James D. Jontes
      Pages 223-249
  5. Cadherins in Tissues and Diseases

    1. Front Matter
      Pages 313-313
    2. Lewis L. Brayshaw, Stephen R. Price
      Pages 315-340
    3. Aziz El-Amraoui, Christine Petit
      Pages 341-361
    4. Lauren V. Albrecht, Kathleen J. Green, Adi D. Dubash
      Pages 363-397
    5. Shinji Hirano, Keiko Imai-Okano
      Pages 399-421

About this book


This book presents an overview of the entire field of cadherin research and provides the current basic concept of cadherins. Cadherins have been widely accepted as key regulators of animal development and physiological functions, and it also has become clear that they play essential roles in various human diseases. With contributions by leading scientists, the book covers various aspects of the cadherin superfamily including the history of cadherin research, basic properties of classical cadherins as well as non-classical cadherins, cadherin-associated proteins, and the roles of cadherins in health and diseases. In addition, the book presents some contradictory results and important unanswered questions, and the authors propose their working hypotheses or future directions, to inspire future studies. This volume enables graduate students and young researchers to learn the basics and gain a comprehensive image of the cadherin superfamily, and experts in the field will easily find various topics of interest in relevant areas of study. Additionally, a list of cadherin-related diseases is included for quick reference to cadherins in human diseases.


Cadherin Cell adhesion molecule Cell biology Animal development Morphogenesis Cell signaling Human disease Nervous system Physiology

Editors and affiliations

  • Shintaro T. Suzuki
    • 1
  • Shinji Hirano
    • 2
  1. 1.Department of BioscienceKwansei Gakuin UniversitySanda, HyogoJapan
  2. 2.Department of Cell BiologyKansai Medical UniversityHirakataJapan

Bibliographic information

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