Paroxysmal Nocturnal Hemoglobinuria

From Bench to Bedside

  • Yuzuru Kanakura
  • Taroh Kinoshita
  • Jun-ichi Nishimura

Table of contents

  1. Front Matter
    Pages i-viii
  2. Wendell Franklyn Rosse
    Pages 1-8
  3. Basic Sciences in PNH

    1. Front Matter
      Pages 9-9
    2. Yusuke Maeda, Yoshiko Murakami, Taroh Kinoshita
      Pages 11-54
    3. Yoshiko Murakami, Taroh Kinoshita
      Pages 55-65
    4. Charles J. Parker
      Pages 67-95
  4. Clinical Sciences in PNH

    1. Front Matter
      Pages 97-97
    2. Robert A. Brodsky
      Pages 99-107
    3. Britta Höchsmann, Hubert Schrezenmeier
      Pages 137-151
    4. Haruhiko Ninomiya, Anita Hill
      Pages 153-172
    5. Hideki Nakakuma, Tsutomu Shichishima, Jun-ichi Nishimura
      Pages 173-183
    6. Lucio Luzzatto
      Pages 197-213
    7. Tatsuya Kawaguchi, Hideki Nakakuma
      Pages 215-227
    8. Norimitsu Inoue, Taroh Kinoshita
      Pages 229-251
    9. Tsutomu Shichishima, Hideyoshi Noji
      Pages 253-269
    10. Jeffrey Szer
      Pages 271-282
    11. Jun-ichi Nishimura, Taroh Kinoshita, Yuzuru Kanakura
      Pages 297-306
    12. Gérard Socié, Régis Peffault de Latour
      Pages 307-317
    13. Naoyuki Miyasaka, Osamu Miura
      Pages 347-358

About this book


This volume reviews the fundamental understanding of this potentially life-threatening disease and the advances in treatment that have been achieved with the use of the monoclonal antibody eculizumab. Although the PIGA gene has been known for many years, the mechanism of clonal dominance in paroxysmal nocturnal hemoglobinuria is still largely unknown. This book, Paroxysmal Nocturnal Hemoglobinuria, discusses the direction of continuing research in this area, as well as the potential for the development of management guidelines. It serves as a valuable source of information for both basic scientists and physicians, especially immunologists targeting GPI-anchored proteins and complements, and hematologists specializing in bone marrow failure.


Marchiafava-Micheli syndrome anemia eculizumab hemolysis red blood cells thrombophilia

Editors and affiliations

  • Yuzuru Kanakura
    • 1
  • Taroh Kinoshita
    • 2
  • Jun-ichi Nishimura
    • 3
  1. 1.Department of Hematology and OcologyOsaka University Graduate School of MedicineSuitaJapan
  2. 2.Immunology Frontier Research CenterOsaka UniversitySuitaJapan
  3. 3.Dept of Hematology and OcologyOsaka University Dept of Hematology and OcologySuitaJapan

Bibliographic information

Industry Sectors
Health & Hospitals
Oncology & Hematology