© 2016

Glycosignals in Cancer: Mechanisms of Malignant Phenotypes

  • Koichi Furukawa
  • Minoru Fukuda


  • Shows how sugar chains are critically involved in malignant phenotypes of cancers

  • Presents a variety of modes by which sugar chains modulate cell signals determining cell fates

  • Explains how up-to-date results of life technology and information are being applied in glycobiology research of cancers

  • Inspires the application of knowledge about signals generated via glycosylation for diagnosis and therapy of cancers


Table of contents

  1. Front Matter
    Pages i-viii
  2. Changes of Glycosylation Machineries in Cancer Cells

    1. Front Matter
      Pages 1-1
    2. Eiji Miyoshi, Naofumi Uozumi, Tomoaki Sobajima, Shinji Takamatsu, Yoshihiro Kamada
      Pages 3-16
    3. Celso A. Reis, Ana Magalhães
      Pages 17-32
  3. Regulation of Cancer Phenotypes by Carbohydrates

    1. Front Matter
      Pages 33-33
  4. Altered Cell Signaling in Cancer Cells

    1. Front Matter
      Pages 55-55
    2. Koichi Furukawa, Yuki Ohkawa, Yasuyuki Matsumoto, Yuhsuke Ohmi, Noboru Hashimoto, Keiko Furukawa
      Pages 57-76
    3. Sen-itiroh Hakomori, Kazuko Handa
      Pages 77-93
    4. Xin Liu, Gerald W. Hart
      Pages 95-108
  5. Regulation of Immune Systems and Cancers by Carbohydrates

  6. Changes in the Organization of Complex Carbohydrates in Cancers

    1. Front Matter
      Pages 139-139
  7. Implication of Sugars in Cancer Diagnostics and Therapeutics

    1. Front Matter
      Pages 195-195
    2. Jung-Tung Hung, Alice L. Yu
      Pages 197-219

About this book


This book is a collection of cutting-edge studies on the functions and mechanisms of glycosylation in cancers. Along with progress in genomics and proteomics, new findings in the significance of these complex carbohydrates, through the regulation of cell signals, have been elucidated in a wide variety of biological events. This volume provides a comprehensive summary of glycosignals and their involvement in cancer, covering numerous topics such as glycosylation machineries, regulation of phenotypes, cell signaling, immune regulation, complex carbohydrate organization, and clinical applications. The contents have been organized to promote ready understanding, covering basic to clinical research and studies on micromolecules, to animal/human cells and tissues. This book is an essential read for students and young researchers interested in cancers and carbohydrates. Specialists in glycobiology will also benefit from the new results and approaches detailed here, which provide insights into future directions of functional studies of sugar chains in both basic and applied research.


Glycosylation Cancer Signal Sugar chain Carbohydrate Therapy

Editors and affiliations

  • Koichi Furukawa
    • 1
  • Minoru Fukuda
    • 2
  1. 1.Biomedical SciencesChubu UniversityKasugaiJapan
  2. 2.Glycobiology UnitSanford-Burnham Med Res InstLa JollaUSA

Bibliographic information

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