Helicobacter pylori Research

From Bench to Bedside

  • Steffen Backert
  • Yoshio Yamaoka

Table of contents

  1. Front Matter
    Pages i-xi
  2. Bacteriology and Molecular Biology

    1. Front Matter
      Pages 1-1
    2. Judyta Praszkier, Philip Sutton, Richard L. Ferrero
      Pages 57-87
    3. Steffen Backert, Giuseppe Zanotti, Judith Lind, Carmen Isabell Asche, Nicole Tegtmeyer
      Pages 89-111
    4. Timothy L. Cover, Robin L. Holland, Steven R. Blanke
      Pages 113-141
    5. Sandy R. Pernitzsch, Fabien Darfeuille, Cynthia M. Sharma
      Pages 189-216
    6. Bram Flahou, Freddy Haesebrouck, Annemieke Smet
      Pages 233-269
  3. Immune Responses and Host Factors

    1. Front Matter
      Pages 271-271
    2. Jay V. Solnick, Kathryn A. Eaton, Richard M. Peek Jr.
      Pages 273-297
    3. Anne Müller, Mara L. Hartung
      Pages 299-323
    4. Hiroko Oshima, Mizuho Nakayama, Masanobu Oshima
      Pages 325-338
    5. Mairi H. McLean, Ruairidh Nicoll, Cheryl Saw, Georgina L. Hold, Emad M. El-Omar
      Pages 339-362
  4. Helicobacter pylori-Associated Diseases

    1. Front Matter
      Pages 363-363
    2. Doron Boltin, Yaron Niv
      Pages 365-385
    3. Robert M. Genta, Richard H. Lash
      Pages 387-402
    4. Richard M. Peek Jr., Lydia E. Wroblewski
      Pages 403-421
    5. Sibylle Koletzko, Francis Mégraud
      Pages 443-467
  5. Treatment of Helicobacter pylori

    1. Front Matter
      Pages 469-469
    2. Javier Molina-Infante, David Y. Graham
      Pages 471-490
    3. Peter Malfertheiner, Michael Selgrad
      Pages 491-502
    4. Javier Torres, Pelayo Correa, Rolando Herrero, M. Blanca Piazuelo, Catterina Ferreccio
      Pages 503-517
    5. Filipa F. Vale, Jorge M. B. Vítor, Mónica Oleastro
      Pages 543-574
    6. Sukanya Raghavan, Marianne Quiding-Järbrink
      Pages 575-601
  6. Back Matter
    Pages 603-613

About this book


This book provides the current updated knowledge on all essential aspects in the rapidly evolving area of Helicobacter pylori research. H. pylori is a class I carcinogen and one of the most common infections in the world. While most people colonized by H. pylori will remain asymptomatic, up to 20 % of them may develop serious gastroduodenal disease such as peptic ulcers or gastric cancer. H. pylori is the only known bacterium linked to the development of cancer and consequently is an important focus of research. Outstanding international experts from diverse scientific disciplines contribute here to give detailed insights into the current understanding concerning the physiology and role of this pathogen. Both basic science and clinical research with actual practical consequences are taken into account. The chapters target microbiology, epidemiology, genetics, biochemistry, interactions with the immune system, signal transduction, pathogenic mechanisms in the gastroduodenal mucosa, gastric disease development, and therapy including antibiotics or probiotics treatment as well as vaccination strategies. This book is an important reference not only for clinicians but also microbiologists. It provides in a single volume an up-to-date summary of our current knowledge of this microbe and the multiple ways in which it impacts upon public health in all parts of the world.


H. pylori Gastric cancer Pathogenesis Eradication therapy Co-evolution

Editors and affiliations

  • Steffen Backert
    • 1
  • Yoshio Yamaoka
    • 2
  1. 1.Division of Microbiology;Dept of BiologyFriedrich Alexander Univ;Erlangen-NurembErlangenGermany
  2. 2.Dept of Medicine-GastroenteologyBaylor College of MedicineHoustonUSA

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