Immunology of the Skin

Basic and Clinical Sciences in Skin Immune Responses

  • Kenji Kabashima

Table of contents

  1. Front Matter
    Pages i-ix
  2. Kenji Kabashima
    Pages 1-11
  3. Components of Skin Immune Cells

    1. Front Matter
      Pages 13-13
    2. Yoshikazu Uchida, Kyungho Park
      Pages 15-30
    3. Koji Sayama
      Pages 31-42
    4. Saeko Nakajima
      Pages 43-56
    5. Takashi Nomura, Aya Shinohara
      Pages 57-94
    6. Kazuhiro Kawai
      Pages 95-111
    7. Manabu Fujimoto
      Pages 113-130
    8. Atsushi Otsuka
      Pages 131-146
    9. Rohit Jain, Andrew J. Mitchell, Szun S. Tay, Ben Roediger, Wolfgang Weninger
      Pages 147-167
    10. Sho Hanakawa, Akihiko Kitoh
      Pages 169-178
    11. Taku Fujimura, Alexander H. Enk
      Pages 179-192
    12. Satoshi Hirakawa, Michael Detmar
      Pages 193-201
    13. Manabu Ohyama, Keisuke Nagao
      Pages 203-211
    14. Risa Tamagawa-Mineoka, Norito Katoh
      Pages 213-226
    15. Satoshi Nakamizo, Gyohei Egawa
      Pages 227-238
  4. Immune Systems in the Skin

    1. Front Matter
      Pages 239-239
    2. Takashi Satoh, Naotomo Kambe
      Pages 241-253
    3. Nobuo Kanazawa
      Pages 255-274
    4. Tatsuyoshi Kawamura
      Pages 295-324
    5. Tetsuya Honda
      Pages 325-337
    6. Hanako Ohmatsu, James G. Krueger
      Pages 359-373
    7. Marcus Maurer, Markus Magerl, Torsten Zuberbier, Karsten Weller
      Pages 375-392
    8. Jun Yamagami, Hayato Takahashi, Masayuki Amagai
      Pages 405-417
    9. Eishin Morita
      Pages 419-427
    10. Fumi Miyagawa, Stephen I. Katz
      Pages 429-449
    11. Kenshi Yamasaki
      Pages 451-462
    12. Simone M. Goldinger, Emmanuella Guenova, Kazuyasu Fujii, Mirjana Urosevic-Maiwald
      Pages 463-475
    13. Yoshihide Asano
      Pages 489-501
  5. Back Matter
    Pages 503-510

About this book


This book reviews the role of each cell subset in the skin, providing the basics for understanding skin immunology and the mechanisms of skin diseases. The skin is one of the immune organs and is continually exposed to foreign antigens and external stimuli that must be monitored and characterized for possible elimination. Upon exposure to foreign antigens, the skin can elicit a variety of immune responses in harmony with skin components that include keratinocytes, dendritic cell subsets, mast cells, basophils, fibroblasts, macrophages, gamma-delta T cells, neutrophils, myeloid-derived suppressor cells, vascular and lymphatic cells, hair follicles, platelets, and adipose tissues, among others. In the past 10 years, knowledge of immunology has expanded drastically in areas such as innate immunity (Toll-like receptors, C-type lectins), and host defenses to bacteria and viruses, and this increased knowledge has led to the development of more effective treatment of psoriasis and other skin diseases. This book provides updates on the mechanisms of skin diseases including contact dermatitis, atopic dermatitis, psoriasis, urticaria, drug eruption, bullous diseases, anaphylaxis, graft-versus-host disease, rosacea, lymphoma, photodermatology, and collagen vascular diseases. Understanding the basics of skin immunology will help clinicians and dermatologists use new therapeutics such as biologics efficiently. Serving as an intermediary between basic science and clinical medicine, this book gives readers the opportunity to understand and marvel at the mystery and fascination of skin immunology.


Skin immunology Barrier functions Allergies Skin diseases Dermatology

Editors and affiliations

  • Kenji Kabashima
    • 1
  1. 1.Department of DermatologyKyoto University Grad Sch of Med.Sakyo-ku, KyotoJapan

Bibliographic information

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