Systemic Sclerosis

  • Kazuhiko Takehara
  • Manabu Fujimoto
  • Masataka Kuwana

Table of contents

  1. Front Matter
    Pages i-viii
  2. Hironobu Ihn
    Pages 1-20
  3. Ayumi Yoshizaki, Shinichi Sato
    Pages 21-37
  4. Masataka Kuwana
    Pages 39-56
  5. Toshiyuki Yamamoto
    Pages 57-79
  6. Naoyuki Tsuchiya, Aya Kawasaki
    Pages 81-92
  7. Masatoshi Jinnin
    Pages 117-136
  8. Manabu Fujimoto, Kazuhiko Takehara
    Pages 137-153
  9. Sei-ichiro Motegi
    Pages 155-171
  10. Takashi Matsushita, Kazuhiko Takehara
    Pages 173-185
  11. Yoshihide Asano
    Pages 187-209
  12. Minoru Hasegawa
    Pages 211-229
  13. Yasuhito Hamaguchi
    Pages 231-247

About this book


​This book provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma). Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune activation. This disease is also associated with certain susceptibility genes and is affected by epigenetic regulation. Recent studies have revealed a variety of new evidence suggestive of the pathogenesis of the disease. These include endothelial progenitor cells, cytokines and growth factors, and B cells. Studies using animal models have also provided novel insight into the pathomechanisms. In addition to these topics, the book covers clinical research regarding biomarkers and autoantibodies. This volume will benefit all rheumatologists and dermatologists as well as basic scientists, especially immunologists, molecular biologists, and biochemists.


Autoimmune disease Cytokine Fibrosis Immune activation Scleroderma Vasculopathy

Editors and affiliations

  • Kazuhiko Takehara
    • 1
  • Manabu Fujimoto
    • 2
  • Masataka Kuwana
    • 3
  1. 1.Department of DermatologyKanazawa UniversityKanazawaJapan
  2. 2.Department of DermatologyUniversity of TsukubaTsukubaJapan
  3. 3.Department of Allergy and RheumatologyNippon Medical SchoolTokyoJapan

Bibliographic information

  • DOI
  • Copyright Information Springer Japan 2016
  • Publisher Name Springer, Tokyo
  • eBook Packages Medicine
  • Print ISBN 978-4-431-55707-4
  • Online ISBN 978-4-431-55708-1
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Consumer Packaged Goods