• Takafumi Ueda
  • Akira Kawai

Table of contents

  1. Front Matter
    Pages i-xi
  2. Basic Research and Experimental Therapy

    1. Front Matter
      Pages 1-1
    2. Junya Toguchida
      Pages 3-17
    3. Tomohide Tsukahara, Takuro Wada
      Pages 31-41
  3. Clinical Features

    1. Front Matter
      Pages 43-43
    2. Koichi Ogura, Hiroaki Hiraga, Takeshi Ishii, Toshifumi Ozaki, Yoshihiro Nishida, Hideo Morioka et al.
      Pages 45-57
  4. Chemotherapy

    1. Front Matter
      Pages 81-81
    2. Hiroaki Hiraga
      Pages 83-96
    3. Shigeki Kakunaga, Takafumi Ueda, Norifumi Naka, Shigeyuki Kuratsu, Nobuhito Araki, Yasuaki Aoki et al.
      Pages 97-106
  5. Surgery

    1. Front Matter
      Pages 107-107
    2. Toshiyuki Kunisada, Ken Takeda, Tomohiro Fujiwara, Shinsuke Sugihara, Toshifumi Ozaki
      Pages 135-147
  6. Surgery: Biological Reconstruction

  7. Unresectable/Metastatic Disease

    1. Front Matter
      Pages 229-229
    2. Shintaro Iwata, Tsukasa Yonemoto, Hiroto Kamoda, Takeshi Ishii
      Pages 245-253
  8. Quality of Life

    1. Front Matter
      Pages 255-255
    2. Tsukasa Yonemoto, Shintaro Iwata, Hiroto Kamoda, Takeshi Ishii
      Pages 257-270

About this book


This book reviews the brilliant progress made in the past three decades in clinical outcomes for osteosarcoma patients treated with a multidisciplinary approach, including limb-salvage surgery combined with neoadjuvant multidrug chemotherapy and aggressive management of pulmonary metastasis. Osteosarcoma was a miserable disease for adolescents and young adults until the early 1970s, with a survival rate that was less than 10–15% even after amputation for affected limbs because of the progression of pulmonary metastasis. With the development of neoadjuvant chemotherapy for osteosarcoma, including high-dose methotrexate, doxorubicin, cisplatin, and ifosfamide during the late 1970s and the 1980s, however, the prognosis has dramatically improved. Limb-salvage surgery for patients with extremity osteosarcoma is now a gold-standard surgical procedure for more than 90% of patients with localized disease. Additionally, aggressive pulmonary metastasectomy for patients with lung metastasis from osteosarcoma has contributed to improvement of their survival. More recently, carbon-ion radiotherapy has also been introduced for patients with unresectable osteosarcoma of the trunk, as in the spine and pelvis. In this volume the author provides valuable descriptions of an important new treatment modality for a multidisciplinary approach for osteosarcoma patients.


doxorubicin ifosfamide limb-salvage surgery methotrexate neoadjuvant chemotherapy pulmonary metastasis

Editors and affiliations

  • Takafumi Ueda
    • 1
  • Akira Kawai
    • 2
  1. 1.Osaka National HospitalOsaka UniversityOsakaJapan
  2. 2.National Cancer Center HospitalTokyoJapan

Bibliographic information

Industry Sectors
Health & Hospitals
Oncology & Hematology
Surgery & Anesthesiology