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Bioactive Lipid Mediators

Current Reviews and Protocols

  • Takehiko Yokomizo
  • Makoto Murakami

Table of contents

  1. Front Matter
    Pages i-ix
  2. Enzymes and Receptors for Lipid Mediators

    1. Front Matter
      Pages 1-1
    2. Hideo Shindou, Takeshi Harayama, Daisuke Hishikawa
      Pages 3-21
    3. Makoto Murakami, Yoshitaka Taketomi
      Pages 23-42
    4. Tomoaki Koga, Takehiko Yokomizo
      Pages 85-93
    5. Kuniyuki Kano, Kumiko Makide, Jun Ishiguro, Hiroshi Yukiura, Shizu Aikawa, Akiharu Uwamizu et al.
      Pages 109-126
    6. Akira Hirasawa, Masato Takeuchi, Takafumi Hara, Ayako Hirata, Soshi Tanabe, Naoya Umeda
      Pages 139-154
    7. Yosuke Isobe, Makoto Arita
      Pages 155-162
  3. Lipid Mediators in Drosophila and Zebrafish

    1. Front Matter
      Pages 163-163
    2. Kohjiro Nagao, Naoto Juni, Masato Umeda
      Pages 165-180
    3. Andrew J. Spracklen, Tina L. Tootle
      Pages 181-197
    4. Yu Hisano, Tsuyoshi Nishi, Atsuo Kawahara
      Pages 207-220
  4. Lipid Mediators and Diseases

    1. Front Matter
      Pages 221-221
    2. Noriko Takuwa, Yasuo Okamoto, Kazuaki Yoshioka, Yoh Takuwa
      Pages 237-252
    3. Utako Yokoyama, Ryo Ishiwata, Yoshihiro Ishikawa
      Pages 267-278
    4. Laura B. Fanning, Joshua A. Boyce
      Pages 279-301
    5. Tetsuya Honda, Kenji Kabashima
      Pages 303-314
  5. Protocols for Analyzing Lipid Mediators

    1. Front Matter
      Pages 329-329
    2. Toshiaki Okuno, Takehiko Yokomizo
      Pages 331-336
    3. Yoshihiro Kita, Takao Shimizu
      Pages 337-347
    4. Tomohiro Takahashi, Daisuke Saigusa, Chihiro Takeda, Kohei Saito, Naoto Suzuki, Hiroki Tsukamoto et al.
      Pages 357-370
    5. Ikuko Yao, Gustavo A. Romero-Pérez, Dan Nicolaescu, Mitsutoshi Setou
      Pages 371-391
    6. Fumiyuki Sasaki, Takehiko Yokomizo
      Pages 409-417
  6. Back Matter
    Pages 419-426

About this book

Introduction

This book summarizes the most recent progress in the studies of lipid mediators from the molecular to clinical level and introduces newly created tools for analysis including imaging mass spectrometry. Comprising 29 chapters divided into four major parts, the book describes the molecular natures of enzymes, transporters, and receptors for lipid mediators (Part I), the function of lipid mediators in Drosophila and Zebrafish (Part II), the relationships between lipid mediators and various diseases (Part III), and detailed procedures of extraction, preparation, and quantification of lipid mediators (Part IV). Research on lipid mediators initially started with analysis of the action of aspirin, and subsequent biochemical experiments identified many enzymes and receptors responsible for the biosynthesis and signal transduction of individual lipid mediators. Through the phenotypic analyses of transgenic and knockout mice, it has been shown that the dysregulation of some lipid mediators causes inflammatory, immune, or oncogenic disorders. Lipid mediators have attracted increased attention because their structures are conserved among different species, and their biosynthetic and signaling pathways have been deciphered at the molecular level. Many drugs that target lipid mediators are already being used in hospitals, and this book suggests further possibilities for development of a wide variety of such drugs. Very recently, highly sensitive mass spectrometry has begun to be used to identify novel lipid mediators that are present only in trace amounts in tissues but with robust biological activity. Written by international experts, this book provides readers a comprehensive view of lipid mediators and related topics and helps in the process of determining research targets for the near future.

Keywords

Eicosanoid Leukotriene Lipid research model animal Lipid research protocol Lipidomics Lysophospholipid Mass spectrometry New drug target Prostaglandin ω3 polyunsaturated fatty acid

Editors and affiliations

  • Takehiko Yokomizo
    • 1
  • Makoto Murakami
    • 2
  1. 1.Department of BiochemistryJuntendo University Graduate School of MedicineTokyoJapan
  2. 2.Lipid Metabolism ProjectTokyo Metropolitan Institute of Medical ScienceTokyoJapan

Bibliographic information

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Pharma