Protein Modifications in Pathogenic Dysregulation of Signaling

  • Jun-ichiro Inoue
  • Mutsuhiro Takekawa

Table of contents

  1. Front Matter
    Pages i-ix
  2. Novel Analytical Procedures for Signal Transduction

    1. Front Matter
      Pages 1-1
    2. Eiji Kinoshita, Emiko Kinoshita-Kikuta, Tohru Koike
      Pages 17-30
    3. Hirotaka Takahashi, Keiichirou Nemoto, Ramadan Abdelaziz, Atsushi Uematsu, Tatsuya Sawasaki
      Pages 43-60
  3. Mathematical Simulation of Signal Transduction

    1. Front Matter
      Pages 61-61
    2. Daisuke Ohshima, Kyoko Arimoto-Matsuzaki, Taichiro Tomida, Mutsuhiro Takekawa, Kazuhisa Ichikawa
      Pages 77-93
    3. Hiroyuki Kubota, Shinya Kuroda
      Pages 95-109
  4. Structural Analysis of Signal Transduction

    1. Front Matter
      Pages 111-111
    2. Kazuki Kato, Hiroshi Nishimasu, Ryohei Ishii, Osamu Nureki, Ryuichiro Ishitani
      Pages 113-125
    3. Teruya Nakamura, Yohei Mukai, Yasuo Tsutsumi, Yuriko Yamagata
      Pages 127-141
  5. Regulation of Signal Transduction by Post-translational Modifications and Its Pathogenic Dysregulation

    1. Front Matter
      Pages 157-157
    2. Shoji Yamaoka
      Pages 159-175
    3. Yuu Taguchi, Jin Gohda, Jun-ichiro Inoue
      Pages 197-210
    4. Mutsuhiro Takekawa, Yuji Kubota
      Pages 211-231
    5. Atsushi Enomoto, Liang Weng, Masahide Takahashi
      Pages 233-250
    6. Hikari Yoshitane, Yoshitaka Fukada
      Pages 251-268
    7. Keiko Taguchi, Masayuki Yamamoto
      Pages 269-285
  6. Back Matter
    Pages 343-348

About this book


This book is devoted to recent advances in analysis of the molecular basis and dynamics of post-translational modifications (PTMs) of proteins for a comprehensive understanding of their key roles in cell signaling networks and diverse biological processes, and their perturbation in a variety of life-threatening diseases such as cancer and inflammatory diseases. The book includes research regarding PTMs and methods of their investigation derived from interdisciplinary collaborations between leading scientists in the fields of molecular, medical, proteomic, structural, and mathematical biology. This book consists of four sections. The first part focuses on recent advances in procedures for analysis of PTMs and cell signaling. The second part is devoted to mathematical simulation of signal transduction pathways and of the formation of protein complexes in living cells. The third part deals with structural and functional analyses of proteins involved in the regulation of PTMs and cell signaling. The fourth part describes cutting-edge findings regarding critical signal transduction pathways and their dysregulation in human diseases. This book is aimed at both established scientists and students in various fields of biology including molecular, cellular, structural, proteomic, and mathematical biology. Readers can access cutting-edge research and methodologies in their own field as well as interdisciplinary research that impacts on their field. The book can function as a reference for pharmaceutical scientists, biomedical researchers, and clinicians for the development of molecular-targeted therapy of human diseases.


Cell signaling Interdisciplinary collaboration Molecular pathophysiology Post-translational modifications Signal transduction

Editors and affiliations

  • Jun-ichiro Inoue
    • 1
  • Mutsuhiro Takekawa
    • 2
  1. 1.Division of Cellular & Molecular Biology, The Institute of Medical ScienceThe University of TokyoTokyoJapan
  2. 2.The Institute of Medical Science Division of Cell Signaling & Molecular MedicineThe University of TokyoTokyoJapan

Bibliographic information

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