A Universal Molecular Nexus for Growth, Survival, and Specialized Metabolism

  • Tomonobu Kusano
  • Hideyuki Suzuki

Table of contents

  1. Front Matter
    Pages i-ix
  2. Biosynthesis of Polyamines

    1. Front Matter
      Pages 1-1
    2. Wakao Fukuda, Ryota Hidese, Shinsuke Fujiwara
      Pages 15-25
    3. Taku Takahashi, Wurina Tong
      Pages 27-44
  3. Catabolism of Polyamines

    1. Front Matter
      Pages 45-45
    2. Hideyuki Suzuki, Shin Kurihara
      Pages 47-59
    3. Tracy Murray-Stewart, Robert A. Casero Jr.
      Pages 61-75
    4. Tomonobu Kusano, Dong Wook Kim, Taibo Liu, Thomas Berberich
      Pages 77-88
  4. Polyamine Homeostasis

    1. Front Matter
      Pages 89-89
    2. Noriyuki Murai
      Pages 91-99
    3. Yoshiyuki Kamio, Yoshihiro Yamaguchi, Jun Kaneko
      Pages 101-109
    4. Sunil Kumar Thalor, Thomas Berberich, Tomonobu Kusano
      Pages 111-118
  5. Roles of Polyamines in Growth

  6. Roles of Polyamines in Survival

    1. Front Matter
      Pages 153-153
    2. Thomas Berberich, G. H. M. Sagor, Tomonobu Kusano
      Pages 155-168
  7. Polyamine Transporters

    1. Front Matter
      Pages 169-169
    2. Shin Kurihara, Hideyuki Suzuki
      Pages 171-178
    3. Miki Fujita, Kazuo Shinozaki
      Pages 179-185
  8. Polyamine-Derived Secondary Metabolites

    1. Front Matter
      Pages 187-187
    2. Xiaofeng Xiong, Kristian Strømgaard
      Pages 201-214
  9. Action of Polyamines on Ion Channels

    1. Front Matter
      Pages 215-215
    2. Keiko Kashiwagi, Keith Williams, Kazuei Igarashi
      Pages 243-253
  10. Polyamines and Longevity

    1. Front Matter
      Pages 255-255
    2. Mitsuharu Matsumoto
      Pages 257-266
    3. Raheel Anwar, Autar K. Mattoo, Avtar K. Handa
      Pages 267-302
  11. Diagnosis and Drug Targets

    1. Front Matter
      Pages 303-303
    2. Masao Kawakita, Kyoko Hiramatsu, Shun-suke Moriya, Keijiro Samejima, Kei-ichi Takahashi
      Pages 305-313
    3. Nahir Velez, Margaret A. Phillips
      Pages 315-329
  12. Back Matter
    Pages 331-336

About this book


This book covers key topics in polyamine research from a range of organisms, including plants, mammals, and prokaryotes such as bacteria and archaea. The book provides an introduction to general concepts in the field of polyamine research, as well as more detailed information. With the availability of genome sequence data from a broad range of organisms, the evolution of the genes involved in polyamine metabolism is discussed. The mode of action of polyamines has been shown to be dependent on cation channels, and this mechanism is described in the book. The origin of polyamine transporters (from bacteria, yeasts, and plants) is described. The various effects of polyamines on growth and survival are also documented. The book details the mechanisms of polyamine homeostasis and the role of polyamine molecules as precursors of secondary metabolites such as plant alkaloids and toxins derived from spiders and wasps. The role of polyamines in longevity and disease is discussed. A link between polyamine contents and cancer progression is reported, as is the use of polyamine metabolites as diagnostic markers in the initial stages of cancer. Moreover, a novel approach that utilizes the polyamine pathway of a parasite as a drug target in African sleeping sickness is described. Therefore, this book is a valuable resource, both as a textbook for undergraduate and graduate students and also as a reference book for front-line polyamine researchers.


biosynthesis catabolism homeostasis ion channel longevity transport

Editors and affiliations

  • Tomonobu Kusano
    • 1
  • Hideyuki Suzuki
    • 2
  1. 1.Graduate School of Life SciencesTohoku University2-1-1 Katahira, Aoba, Sendai-cityJapan
  2. 2.Graduate School of Science and TechnologyKyoto Institute of TechnologyGoshokaido-cho, Matsugasaki, Sakyo-kuJapan

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