Table of contents

  1. Front Matter
    Pages i-xii
  2. Wolfgang Maret
    Pages 7-26
  3. Taiho Kambe, Tokuji Tsuji, Kazuhisa Fukue
    Pages 27-53
  4. Hirokazu Hara, Elias Aizenman
    Pages 55-87
  5. Keigo Nishida, Satoru Yamasaki
    Pages 89-109
  6. Anne M. Hessels, Maarten Merkx
    Pages 135-159
  7. Atsushi Takeda
    Pages 161-181
  8. Sara M. Hancock, Ashley I. Bush, Paul A. Adlard
    Pages 183-196
  9. Lothar Rink, Martina Maywald
    Pages 197-226
  10. Ming-Jie Liu, Daren L. Knoell
    Pages 227-248
  11. Toshiyuki Fukada, Shintaro Hojyo, Bum-Ho Bin
    Pages 249-267
  12. Yoshio Fujitani, Motoyuki Tamaki, Ayako Fukunaka, Hirotaka Watada
    Pages 269-283
  13. Thirayost Nimmanon, Kathryn M. Taylor
    Pages 285-313
  14. Ru Ya, Emily L. Que, Thomas V. O’Halloran, Teresa K. Woodruff
    Pages 315-333
  15. Back Matter
    Pages 335-343

About this book


This book describes the crucial role of "zinc signals" in biological processes on a molecular and physiological basis, discussing future directions and questions underlying this unique phenomenon. To accomplish this, a group of worldwide leaders in the field, who have made outstanding contributions, overview zinc signals from a professional standpoint. Zinc plays an indispensable role in various cellular processes. It regulates a great number of protein functions including transcription factors, enzymes, adapters, and growth factors as a structural or catalytic factor or both. Recently, another function of zinc has received extensive interest and attention because of its potential importance as a signaling mediator. Zinc plays a dynamic role as an intracellular and extracellular signaling factor and thus regulates cellular signaling pathways, which enables communication between cells, conversion of extracellular stimuli to intracellular signals, and control of various intracellular events. These functions of zinc have become recognized as “zinc signals,” which play critical roles in physiology, and therefore their imbalance can cause a variety of problems with regard to human health. Because the notion of zinc signals is quite new and no integrative review books focusing on them have yet been published, we believe this book will provide very timely information on the subject and thus should be of importance and interest to a wide range of readers.


Cancer Immunity Inflammation Metallothionein Physiology Zinc receptors Zinc signals Zinc transporters

Editors and affiliations

  • Toshiyuki Fukada
    • 1
  • Taiho Kambe
    • 2
  1. 1.Laboratory for Homeostatic NetworkRIKEN Center for Integrative Medical SciencesYokohamaJapan
  2. 2.Division of Integrated Life Science, Graduate School of BiostudiesKyoto UniversityKyotoJapan

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