Lens Epithelium and Posterior Capsular Opacification

  • Shizuya Saika
  • Liliana Werner
  • Frank J. Lovicu

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Lens Epithelial Cell Biology

    1. Front Matter
      Pages 1-1
    2. Steven Bassnett
      Pages 25-38
    3. Judith A. West-Mays, Anna Korol
      Pages 39-57
    4. F. J. Lovicu, L. Iyengar, L. J. Dawes, J. W. McAvoy
      Pages 59-80
    5. Robb U. de Iongh, Melinda K. Duncan
      Pages 81-104
    6. Konstantinos Sousounis, Kenta Nakamura, Panagiotis A. Tsonis
      Pages 131-141
    7. I. M. Wormstone, J. A. Eldred, L. J. Dawes
      Pages 143-158
    8. Kumi Shirai, Ai Kitano-Izutani, Takeshi Miyamoto, Sai-ichi Tanaka, Shizuya Saika
      Pages 159-174
  3. Clinical Science: Pathology

    1. Front Matter
      Pages 175-175
    2. Takeshi Miyamoto, Nobuyuki Ishikawa, Kumi Shirai, Ai Kitano-Izutani, Sai-ichi Tanaka, Shizuya Saika
      Pages 177-188
    3. Shannon Stallings, Liliana Werner
      Pages 189-203
  4. Clinical Outcomes

  5. Surgical Methods for PCO Prevention

    1. Front Matter
      Pages 235-235
    2. Erica Liu, Nick Mamalis, Liliana Werner
      Pages 279-293
  6. Intraocular Lense/Devices and PCO

    1. Front Matter
      Pages 295-295
    2. Caleb Morris, Liliana Werner, Manfred Tetz
      Pages 297-312
    3. Okihiro Nishi, Kayo Nishi, Rupert Menapace
      Pages 327-342
    4. Anne Floyd, Liliana Werner, Nick Mamalis
      Pages 357-372
  7. Special Cases

    1. Front Matter
      Pages 397-397
    2. Abhay R. Vasavada, Sajani K. Shah, Vaishali Vasavada, M. R. Praveen
      Pages 399-417
  8. Back Matter
    Pages 419-424

About this book


This book is the first to summarize the current knowledge of the cell biology of lens epithelial cells in relation to and in the development of posterior capsular opacification (PCO). PCO remains the most common long-term complication of modern cataract surgery, occurring months or years after cataract surgery, unlike most other complications that tend to arise during or soon after the procedure. Opacification of the posterior capsule appears to be linked to lens epithelial cells that are left behind in the eye during cataract removal. These cells proliferate, migrate across the posterior lens capsule, and undergo changes that result in fibrous or pearl-type opacities in the capsule.

The first section of the text explains the molecular mechanism and biology of lens epithelial cells that lead to the incidence of PCO. In the second part, in addition to a description of the mechanism and pathological condition of PCO, surgical methods and devices for preventing PCO are discussed in detail. Lens Epithelium and Capsular Opacification will benefit not only young clinical residents and junior researchers, but also established faculty in the clinical or basic academic field.  


biomaterial cataract surgery growth factor intraocular lens lens epithelial cell postoperative capsular opacification

Editors and affiliations

  • Shizuya Saika
    • 1
  • Liliana Werner
    • 2
  • Frank J. Lovicu
    • 3
  1. 1.Department of OphthalmologyWakayama Medical University School of MedicineWakayamaJapan
  2. 2.John A. Moran Eye Center University of UtahSalt Lake CityUSA
  3. 3.School of Medical Sciences Anatomy & HistologyLens Research Laboratory The University of SydneySydneyAustralia

Bibliographic information

  • DOI
  • Copyright Information Springer Japan 2014
  • Publisher Name Springer, Tokyo
  • eBook Packages Medicine
  • Print ISBN 978-4-431-54299-5
  • Online ISBN 978-4-431-54300-8
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals