Th 17 Cells: Role in Inflammation and Autoimmune Disease

  • Valérie Quesniaux
  • Bernhard Ryffel
  • Franco Di Padova

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Introduction

    1. Franco Di Padova, Bernhard Ryffel, Valérie Quesniaux
      Pages 1-9
  3. Discovery and IL-17 family

    1. Front Matter
      Pages 11-11
    2. Robert Sabat, Katrin Witte, Kerstin Wolk
      Pages 13-38
    3. Marie-Laure Miche, Maria C. Leite-de-Moraes
      Pages 39-48
    4. Daniel Mucida, Hilde Cheroutre
      Pages 61-68
    5. Pornpimon Angkasekwinai, Chen Dong
      Pages 69-80
  4. Experimental models of disease

    1. Front Matter
      Pages 81-81
    2. Marije I. Koenders, Wim B. van den Berg
      Pages 83-94
    3. Bruno Schnyder, Silvia Schnyder-Candrian
      Pages 95-104
    4. Isabelle Couillin, Pamela Gasse, Francois Huaux, Silvia Schnyder-Candrian, Bruno Schnyder, François Erard et al.
      Pages 105-113
    5. Alan Valaperti, Urs Eriksson
      Pages 115-126
    6. Ye Chen, Kathryn J. Wood
      Pages 127-132
  5. Role of IL-23/IL-17 in infection and tumor control

    1. Front Matter
      Pages 133-133
    2. Andrea M. Cooper
      Pages 135-147
    3. Shabaana A. Khader, Jay K. Kolls
      Pages 149-159
  6. IL-17 in clinical autoimmune disease

    1. Front Matter
      Pages 173-173
    2. Pierre Miossec
      Pages 175-184
    3. Aaron J. Martin, Stephen D. Miller
      Pages 185-199
    4. Anders Lindén
      Pages 201-209
    5. Isabelle Wolowczuk, Matthieu Allez, Mathias Chamaillard
      Pages 211-224
  7. Novel tools and therapeutic avenues

    1. Front Matter
      Pages 225-225
  8. Back Matter
    Pages 241-246

About this book


With the recent definition of the Th17 cell subset, a new paradigm in innate and adaptive immunity has been established. This book describes the function of the Th17 cell subset and its prevalent role in many inflammatory and autoimmune diseases. The mechanism by which this T cell subset is generated and maintained shows specific differences between mice and man which are reviewed. One characteristic of Th17 cells is to secrete specific and unique cytokines such as IL-17A, IL-17F and IL-22; their functions are described in detail. These cytokines have acquired a prevalent role in many pathological conditions in animal models and in humans. Targeting these cytokines as well as the generation of Th17 cells may open new ways to treat many autoimmune diseases. The role of Th17 in infectious conditions is also addressed.


Arthritis Autoimmune diseases Immunity Promoter allergic disorders asthma autoimmune disease immune surveillance infectious inflammation inflammatory response tissue transplantation tuberculosis tumor control

Editors and affiliations

  • Valérie Quesniaux
    • 1
  • Bernhard Ryffel
    • 1
  • Franco Di Padova
    • 2
  1. 1.Molecular Immunology and EmbryologyUniversity of Orléans and CNRS UMR6218OrléansFrance
  2. 2.Novartis Institutes for Biomedical ResearchNIBR WSJ 386-906BaselSwitzerland

Bibliographic information

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