Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy

  • Carlos A. Zarate
  • Husseini K. Manji

Part of the Milestones in Drug Therapy book series (MDT)

Table of contents

  1. Front Matter
    Pages I-XII
  2. Bipolar depression: Clinical phenotype and course of illness

    1. Front Matter
      Pages 1-1
    2. Andreas Marneros
      Pages 3-16
    3. Gordon B. Parker, Kathryn Fletcher
      Pages 17-28
    4. Zoltán Rihmer
      Pages 47-56
  3. Bipolar depression: Neurobiology

    1. Front Matter
      Pages 57-57
    2. Thomas G. Schulze, Francis J. McMahon
      Pages 59-76
    3. Jun-Feng Wang, L. Trevor Young
      Pages 77-94
    4. Jonathan Savitz, Wayne C. Drevets
      Pages 117-144
  4. Acute and long-term treatment of bipolar disorder

    1. Front Matter
      Pages 145-145
    2. Gary S. Sachs, Louisa G. Sylvia, Hannah G. Lund
      Pages 147-158
    3. Carlos A. Zarate Jr, Husseini K. Manji
      Pages 191-209
  5. Treatment of bipolar disorder in special populations

    1. Front Matter
      Pages 211-211
    2. John L. Beyer, K. Ranga R. Krishnan
      Pages 213-239
    3. Robert L. Findling
      Pages 241-252
    4. Patricia Roy, Jennifer L. Payne
      Pages 253-269
    5. Carlos A. Zarate Jr, Husseini K. Manji
      Pages 271-274
  6. Back Matter
    Pages 275-281

About this book


Although our knowledge of mood disorders in general is expanding steadily, comparatively little is known about bipolar depression in particular. This book brings together leading clinicians and preclinical and clinical researchers to offer the most up-to-date information about the diagnosis, treatment, and research surrounding bipolar depression.

Early chapters provide valuable diagnostic information, and review the course, outcome, and genetics of this highly heritable condition, allowing clinicians to distinguish between the various mood disorders. The book offers a thorough and unique overview of the neurobiology of the disorder, including what is known from recent neuroimaging work. Several chapters delineate the treatment of bipolar depression in special populations such as children and pregnant women, and another chapter addresses the particular issues of suicide, focusing on the need for assessment during both acute and maintenance treatment with interventions appropriate to a patient's symptoms and history. Finally, the book covers acute and long-term treatment strategies for bipolar depression, including both traditional and novel therapeutics for the disorder, as well as non-pharmacological treatments.

This book has assembled a widely respected group of preclinical and clinical researchers who bring their expertise to bear upon this illness. It offers researchers, clinicians, and postgraduate students key insights into this devastating disorder.


Bipolar Depression Focusing Neuroscience Pharmacotherapy assessment bipolar disorder depression diagnosis genetics intervention mood disorder neurobiology neuroimaging suicide women

Editors and affiliations

  • Carlos A. Zarate
    • 1
  • Husseini K. Manji
    • 2
  1. 1.Mood Disorders Research Unit Laboratory of Molecular PathophysiologyNational Institute of Mental Health Mark O. Hatfield Clinical Research CenterBethesdaUSA
  2. 2.Laboratory of Molecular PathophysiologyNational Institute of Mental Health Porter Neuroscience Research CenterBethesdaUSA

Bibliographic information

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