Bone Morphogenetic Proteins: From Local to Systemic Therapeutics

  • Slobodan Vukicevic
  • Kuber T. Sampath

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Slobodan Vukicevic, Kuber Sampath
    Pages 1-5
  3. Christina Sieber, Gerburg K. Schwaerzer, Petra Knaus
    Pages 81-114
  4. Petra Seemann, Stefan Mundlos, Katarina Lehmann
    Pages 141-159
  5. Nandini Ghosh-Choudhury, Goutam Ghosh-Choudhury
    Pages 161-178
  6. Stephen E. Harris, Wuchen Yang, Jelica Gluhak-Heinrich, Dayong Guo, Xiao-Dong Chen, Marie A. Harris et al.
    Pages 179-197
  7. Jelica Gluhak-Heinrich, Dayong Guo, Wuchen Yang, Lilia E. Martinez, Marie A. Harris, Holger Kulessa et al.
    Pages 199-211
  8. David J. J. de Gorter, Carola Krause, Peter ten Dijke, Clemens W. G. M. Löwik, Rutger L. van Bezooijen
    Pages 257-276
  9. Susan Chubinskaya, Mark Hurtig, David C. Rueger
    Pages 277-315
  10. Slobodan Vukicevic, Petra Simic, Lovorka Grgurevic, Fran Borovecki, Kuber Sampath
    Pages 317-337
  11. Back Matter
    Pages 339-346

About this book


Tissue engineering is gaining interest as it is applied for regeneration of organs to attain their lost function. Although resorbable scaffolds and progenitor cell types are required principles to engineer a functional tissue locally, the inductive signal is a prerequisite to trigger the growth and differentiation of responding cells in space and time. Bone morphogenetic proteins (BMPs), also called growth and differentiation factors (GDFs), originally identified from bone have been successfully used to regenerate the bone in humans. Most recent preclinical data suggests that BMPs have a potential to provide protection against inflammation and fibrosis in acute and chronic injury of parenchymal tissues when applied systemically to sustain the function of kidney and liver. The application of BMPs from a local to systemic utility is a rapidly growing field, gaining interest among researchers and biotech entrepreneurs.

In this volume, we summarize the advances made on the local and systemic use of BMPs including chapters covering the regulation of BMP-signalling pathways, biological actions of BMPs in bone, cartilage and teeth, as well as clinical applications and potential systemic use of BMPs for tissues beyond bone.

This volume is of interest to researchers from immunology, cell biology, biochemistry, and clinicians from orthopedics and dentistry, as well as to research managers from biotech and pharmaceutical companies.


Tissue Engineering biochemistry biology bone cartilage cell biology cells chemistry immunology pharmaceutical protein proteins regeneration regulation tissue

Editors and affiliations

  • Slobodan Vukicevic
    • 1
  • Kuber T. Sampath
    • 2
  1. 1.School of Medicine Inst. Anatomy Drago PerovicUniversity of ZagrebZagrebCroatia
  2. 2.Genzyme CorporationFraminghamUSA

Bibliographic information

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