© 2006

In Vivo Models of Inflammation

  • Christopher S. Stevenson
  • Lisa A. Marshall
  • Douglas W. Morgan


  • Revised and extended 2nd edition of this reference manual in two volumes

  • New models from emerging areas of research have been added

  • Provides detailed descriptions of the methodologies and uses of the most significant animal models


Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-x
  2. William M. Selig, Eric T. Whalley, James L. Ellis
    Pages 1-28
  3. Christopher S. Stevenson, David C. Underwood
    Pages 29-57
  4. Lawrence S. Chan
    Pages 85-120
  5. Pierangelo Geppetti, Serena Materazzi, Paola Nicoletti, Marcello Trevisani
    Pages 121-135
  6. Sreekant Murthy
    Pages 137-174
  7. H. Andreas Kalmes, Christopher F. Toombs
    Pages 175-197
  8. Back Matter
    Pages 199-206

About this book


In Vivo Models of Inflammation provides the biomedical researcher in both the pharmaceutical industry and academia with a description of the state of the art animal model systems used to emulate diseases with components of inflammation. This second edition acts as a complement to the first edition by describing and updating the standard models that are most utilized for specific disease areas. In addition, new models are included exploring emerging areas of inflammation research.

The format is designed with the laboratory in mind: Both volumes provide detailed descriptions of the methodologies and uses of the most significant models. This includes current information regarding agents that demonstrate efficacy, those that do not and those that can be used as standard controls. The focus remains on those models that serve as pre-clinical correlates to human disease as well as those that represent components of the inflammatory response.

Pioneering ideas and provocative comments about future directions are meant to challenge the status quo and stimulate new thinking. Therefore, new approaches to the development of future models in selected therapeutic areas have been highlighted. The focus on novel technologies that are vital for innovative in vivo research has been expanded to include chapters on the use of transgenic and gene transfer technologies, nanotechnology, and stem cells.

This up-to-date reference manual helps to select the best animal model for a specific question. At the same time, this set of books continues to acknowledge the solemn responsibility in vivo research carries with it and extends the coverage of animal respect and welfare when used in experimental settings. Chapters describing current regulations in the United States, United Kingdom, and Japan address these concerns.

Thus, the ultimate aim of this set of books is to provide current best practices for obtaining the maximum information from in vivo experimentation, while preserving the dignity and comfort of the animal.


Animal model Arthritis Cancer Cardiovascular diseases Gene transfer technology Neuroinflammation Skin inflammation Stem cells Vivo asthma gene transfer inflammatory response

Editors and affiliations

  • Christopher S. Stevenson
    • 1
  • Lisa A. Marshall
    • 2
  • Douglas W. Morgan
    • 3
  1. 1.Novartis Institutes for Biomedical Research Respiratory Disease AreaNovartis Horsham Research CentreHorsham, West SussexUK
  2. 2.Johnson and Johnson PRDSpring HouseUSA
  3. 3.Portfolio, Program and Alliance Management BiogenIdecCambridgeUSA

Bibliographic information

  • Book Title In Vivo Models of Inflammation
  • Editors Christopher S. Stevenson
    Lisa A. Marshall
    Douglas W. Morgan
  • Series Title Progress in Inflammation Research
  • DOI
  • Copyright Information Birkhäuser Verlag 2006
  • Publisher Name Birkhäuser Basel
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-7643-7757-1
  • eBook ISBN 978-3-7643-7760-1
  • Edition Number 2
  • Number of Pages X, 203
  • Number of Illustrations 19 b/w illustrations, 0 illustrations in colour
  • Additional Information Originally published in one volume under: Marshall, L.A.
  • Topics Immunology
    Infectious Diseases
    Cell Biology
  • Buy this book on publisher's site
Industry Sectors
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