Systems Biological Approaches in Infectious Diseases

  • Helena I. Boshoff
  • Clifton E. BarryIII

Part of the Progress in Drug Research book series (PDR, volume 64)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Michael P. Stumpf, Brian D. Robertson, Ken Duncan, Douglas B. Young
    Pages 1-20
  3. Jesper Højer-Pedersen, Jørn Smedsgaard, Jens Nielsen
    Pages 103-129
  4. Jorrit J. Hornberg, Frank J. Bruggeman, Barbara M. Bakker, Hans V. Westerhoff
    Pages 171-189
  5. Michael Strong, David Eisenberg
    Pages 191-215
  6. Dirk Schnappinger
    Pages 311-343
  7. Back Matter
    Pages 345-349

About this book


Systems biology is an emerging discipline that studies the underlying network structure and the dynamics of metabolism, cells or whole organisms. It aims to investigate all interacting components simultaneously and requires data from high throughput techniques. These data from the "omic" sciences are computed and used to build in silico models of biological systems that ultimately will prove to be an invaluable tool in drug development.

This book brings together the various fields of functional genomics and systems biology that provide information on metabolic function with a special emphasis on the identification of drug targets. It includes practical examples from the various "omic" sciences as well as theoretical examples of how integrated knowledge of these sciences can be applied to drug discovery. It is of interest to researchers in the pharmaceutical drug discovery environment, as well as those in the academic field with an interest in the functional application of the "omic" sciences.


Anästhesie-Informations-Management-System Bacillus subtilis antibiotics bacteria bacterial pathogens biology cells dynamics genetics genome infectious infectious disease infectious diseases protein toxicology

Editors and affiliations

  • Helena I. Boshoff
    • 1
  • Clifton E. BarryIII
    • 1
  1. 1.Tuberculosis Research Section, Laboratory of ImmunogeneticsNational Institute of Allergy and Infectious DiseasesRockvilleUSA

Bibliographic information

Industry Sectors
Health & Hospitals