© 2007

Chemokine Biology — Basic Research and Clinical Application

Volume II: Pathophysiology of Chemokines

  • Kuldeep Neote
  • Gordon L. Letts
  • Bernhard Moser
  • Comprehensive and up-to-date overview of the field

  • Both volumes complement each other, but can also be used independently from each other

  • Written by leading experts in the field

  • The volume editors organized several international conferences on chemokines


Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Chemokines in animal disease models

    1. Front Matter
      Pages 1-1
    2. Steven L. Kunkel, Nuria Godessart, Cory Hogaboam, Stephen W. Chensue, Nicholas Lukacs
      Pages 3-17
    3. William J. Karpus
      Pages 19-26
    4. Zamaneh Mikhak, Andrew D. Luster
      Pages 27-41
  3. Chemokines as drug targets

    1. Front Matter
      Pages 43-43
    2. Amanda E. I. Proudfoot, Christine A. Power, Matthias Schwarz, Timothy N. C. Wells
      Pages 45-59
    3. Tassie L. Collins, Michael G. Johnson, Julio C. Medina
      Pages 79-88
    4. John R. White, Henry M. Sarau
      Pages 89-102
    5. Ronald P. Gladue, Matthew F. Brown
      Pages 103-113
    6. Paul J. Higgins, C. Eric Schwartz, Jean-Marie Nicolas
      Pages 115-123
    7. Louis M. Pelus, Hal E. Broxmeyer
      Pages 125-144
  4. Back Matter
    Pages 165-170

About this book


Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV.
Volume 2 of this two-volume set discusses the pathophysiology of chemokines. It is divided into two parts: a) chemokines in animal disease models, and b) chemokines as drug targets. Together with volume 1, which discusses the immunobiology of chemokines, both volumes give a comprehensive overview of chemokine biology.


Chemokine HIV autoimmune disease biology cell diseases drug immune response inflammation microorganisms pathophysiology physiology research skin tissue

Editors and affiliations

  • Kuldeep Neote
    • 1
  • Gordon L. Letts
    • 2
  • Bernhard Moser
    • 3
  1. 1.Lilly Corporate CenterCancer Inflammation and Cell Survival Eli Lilly and CompanyIndianapolisUSA
  2. 2.NitroMed, Inc.BedfordUSA
  3. 3.Theodor Koch InstituteUniversity of BernBernSwitzerland

Bibliographic information

  • Book Title Chemokine Biology — Basic Research and Clinical Application
  • Book Subtitle Volume II: Pathophysiology of Chemokines
  • Editors Kuldeep Neote
    L. Gordon Letts
    Bernhard Moser
  • Series Title Progress in Inflammation Research
  • DOI
  • Copyright Information Birkhäuser Verlag AG 2007
  • Publisher Name Birkhäuser Basel
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-7643-7195-1
  • eBook ISBN 978-3-7643-7437-2
  • Edition Number 1
  • Number of Pages XII, 171
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Immunology
    Cell Biology
  • Buy this book on publisher's site
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Health & Hospitals