Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma

  • Alexander Baethmann
  • Oliver S. Kempski
  • Nikolaus Plesnila
  • Frank Staub

Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 66)

Table of contents

  1. Front Matter
    Pages I-VIII
  2. Molecular and Cell Biological Mechanisms — Inflammatory Processes

    1. Christoph Wiessner, P. Vogel, T. Neumann-Haefelin, K.-A. Hossmann
      Pages 1-7
    2. Bo. K. Siesjö, K. I. Katsura, T. Kristián, P.-A. Li, P. Siesjö
      Pages 8-14
    3. R. Linde, H. Laursen, A. J. Hansen
      Pages 15-20
    4. Michael Chopp, Y. Li
      Pages 21-26
    5. Kyuya Kogure, Y. Yamasaki, Y. Matsuo, H. Kato, H. Onodera
      Pages 40-43
  3. Novel Findings on Mechanisms and Treatment of Cerebral Ischemia

    1. T. P. Obrenovitch
      Pages 50-55
    2. Frank Staub, A. Winkler, J. Haberstok, N. Plesnila, J. Peters, R. C. C. Chang et al.
      Pages 56-62
    3. N. H. Diemer, T. Balchen, T. Bruhn, T. Christensen, I. Vanicky, M. Nielsen et al.
      Pages 73-75
    4. Cesare Fieschi, C. Cavalletti, D. Toni, M. Fiorelli, M. L. Sacchetti, M. De Michele et al.
      Pages 76-80
  4. Recent Observations on Mechanisms, Regeneration, and Treatment in Head Injury

    1. S. Engel, H. D. Wehner, R. Meyermann
      Pages 87-95
    2. D. I. Graham, S. M. Gentleman, J. A. R. Nicoll, M. C. Royston, J. E. McKenzie, G. W. Roberts et al.
      Pages 96-102
    3. Georg W. Kreutzberg
      Pages 103-106
    4. Edward D. Hall, P. K. Andrus, S. L. Smith, J. A. Oostveen, H. M. Scherch, B. S. Lutzke et al.
      Pages 107-113
  5. Back Matter
    Pages 122-123

About these proceedings


The publication of the Vth International Symposium 1995 on "Mechanisms of Secondary Brain Damage" in Mauls/ltaly is a collection of focused reviews reaching from novel molecular- and cell biological findings to aspects of clinical management in head injury and cerebral ischemia. A specific purpose of these series of meetings introduced in 1984 is for an exchange on problems of mutual interest by international high ranking experts from the basic sciences and related clinical disciplines, such as intensive care medicine, neurology, or neurosurgery. The present volume covers three major areas: (a) Molecular and cell biological mechanisms including inflammation (b) Novel findings on mechanisms and treatment in cerebral ischemia (c) Secondary processes in head injury, regeneration and treatment Molecular-and cell biology is currently attracting attention towards activation of genomic processes associated with the demise of cells referred to as "programmed cell death" and "apoptosis" which, actually, might be distinguished from each other. Thus, the phenomenon of delayed neuronal death in selectively vulnerable brain areas following brief interruption of blood flow is scrutinized as to the contribution of the activation of suicide genes. The physiological role of such a response, among others, is removal of surplus neurons during ontogenesis of the brain. Yet, evidence is accumulating that similar mechanisms playa role in cerebral ischemia, probably also trauma, where nerve-and other cells demonstrate features of apoptosis. Observations on protection of neurons by administration of protein synthesis inhibitors in cerebral ischemia provide more direct support.


Alzheimer Trauma intensive care medicine neurology neurosurgery

Editors and affiliations

  • Alexander Baethmann
    • 1
  • Oliver S. Kempski
    • 2
  • Nikolaus Plesnila
    • 1
  • Frank Staub
    • 3
  1. 1.Institut für Chirurgische Forschung, Klinikum GrosshadernLudwig-Maximilians-UniversitätMünchenFederal Republic of Germany
  2. 2.Institut für Neurochirurgische PathophysiologieJohannes-Gutenberg-UniversitätMainzFederal Republic of Germany
  3. 3.Klinik für NeurochirurgieUniversität zu KölnKölnFederal Republic of Germany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Vienna 1996
  • Publisher Name Springer, Vienna
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-7091-9467-6
  • Online ISBN 978-3-7091-9465-2
  • Series Print ISSN 0065-1419
  • Buy this book on publisher's site
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Surgery & Anesthesiology