© 1993

Combined Effects of Drugs and Toxic Agents

Modern Evaluation in Theory and Practice


Table of contents

  1. Front Matter
    Pages I-XI
  2. Gerald Pöch
    Pages 54-66
  3. Gerald Pöch
    Pages 67-75
  4. Gerald Pöch
    Pages 76-82
  5. Gerald Pöch
    Pages 83-88
  6. Gerald Pöch
    Pages 117-121
  7. Gerald Pöch
    Pages 130-131
  8. Back Matter
    Pages 132-167

About this book


Scientists struggling with the pharmaco- and toxicodynamic interactions of drugs and chemicals will find this book a valuable reference to the relevant theoretical background of this complex field and an indispensible guide to practical, analytical procedures for evaluation of experimental data. A new, straightforward mechanistically based analysis of observed combination effects is backed up by numerous examples as well as by computer-assisted plotting and curve fitting – using popular graphical software systems. The reader thus can gain not only a modern understanding of this complex area but proceed directly to the evaluation of his own dose-response experiments with respect to independent actions, and additive interactions, where appropriate. The meanings of terms and acronyms in the literature, most of them used in this book also, are elucidated by a comprehensive glossary. This book represents a modern, theoretical and practical guide for all scientists dealing with this controversial and complex area of the action and interaction of drugs and chemicals.


biochemistry chemotherapy drug infection infections pathophysiology pharmacology physiology research toxicology

Authors and affiliations

  1. 1.Institut für Pharmakologie und ToxikologieUniversität GrazGrazAustria

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