© 1992

Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors

  • C. Marescaux
  • M. Vergnes
  • R. Bernasconi
Conference proceedings

Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 35)

Table of contents

  1. Front Matter
    Pages I-VII
  2. P. Loiseau
    Pages 1-6
  3. C. Marescaux, M. Vergnes, A. Depaulis
    Pages 37-69
  4. G. Avanzini, M. de Curtis, C. Marescaux, F. Panzica, R. Spreafico, M. Vergnes
    Pages 85-95
  5. R. Pumain, J. Louvel, M. Gastard, I. Kurcewicz, M. Vergnes
    Pages 97-108
  6. A. Nehlig, M. Vergnes, C. Marescaux, S. Boyet
    Pages 141-153
  7. R. Bernasconi, J. Lauber, C. Marescaux, M. Vergnes, P. Martin, V. Rubio et al.
    Pages 155-177
  8. C. Marescaux, M. Vergnes, R. Bernasconi
    Pages 179-188
  9. Back Matter
    Pages 197-200

About these proceedings


Generalized non convulsive epilepsy (GNCE), also called absence or petit mal epilepsy, is a disease appearing during childhood. EEG, clinical, pharmacological and genetic characteristics differ from those of convulsive or focal epilepsies. No underlying structural or biochemical abnormality has been identified for generalized absence seizures and the etiology of this disorder is unknown. It is unlikely that the precise pathophysiology of GNCE can be resolved in studies that focus on humans. Therefore a number of animal models reproducing the human disease have been developed. The aim of this supplementum is to characterize such models in rodents. First, recent models are extensively described. These include the genetic model of spontaneous GNCE in Strasbourg's Wistar rats and in tottering mice as well as bilateral spike and wave discharges induced by GHB, PTZ or GABA mimetics. Second, this supplementum will also provide very recent information on putative mechanisms underlying generalized absence seizures. Third, various experimental approaches aimed at investigating the neural substrate of this particular kind of epilepsy are described with various electrophysiological, pharmacological, biochemical, metabolic, ionic and molecular data. This supplementum provides an original multidisciplinary approach to the mechanisms involved in GNCE and demonstrates that rodent models are a promising tool which complements the classical feline penicillin model.


Epilepsie GABA electroencephalography (EEG) metabolism pathophysiology physiology research

Editors and affiliations

  • C. Marescaux
    • 1
  • M. Vergnes
    • 2
  • R. Bernasconi
    • 3
  1. 1.Clinique NeurologiqueHôpital CivilStrasbourgFrance
  2. 2.Centre de NeurochimieC.N.R.S.StrasbourgFrance
  3. 3.Pharma DivisionCiba-Geigy AGBaselSwitzerland

Bibliographic information

  • Book Title Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors
  • Editors C. Marescaux
    M. Vergnes
    R. Bernasconi
  • Series Title Journal of Neural Transmission
  • DOI
  • Copyright Information Springer-Verlag Vienna 1992
  • Publisher Name Springer, Vienna
  • eBook Packages Springer Book Archive
  • Softcover ISBN 978-3-211-82340-8
  • eBook ISBN 978-3-7091-9206-1
  • Series ISSN 0303-6995
  • Edition Number 1
  • Number of Pages VII, 200
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Neurosciences
  • Buy this book on publisher's site
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