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© 1998

MAO — The Mother of all Amine Oxidases

  • J. P. M. Finberg
  • M. B. H. Youdim
  • P. Riederer
  • K. F. Tipton
Conference proceedings

Part of the Journal of Neural Transmission. Supplement book series (NEURAL SUPPL, volume 52)

Table of contents

  1. Front Matter
    Pages I-XIX
  2. N. G. G. M. Abeling, A. H. van Gennip, A. G. van Cruchten, H. Overmars, H. G. Brunner
    Pages 9-15
  3. D. L. Murphy, K. Sims, G. Eisenhofer, B. D. Greenberg, T. George, F. Berlin et al.
    Pages 29-38
  4. D. L. Murphy, F. Karoum, D. Pickar, R. M. Cohen, S. Lipper, A. M. Mellow et al.
    Pages 39-48
  5. S. Hocherman, G. Levin, N. Giladi, M. B. H. Youdim
    Pages 63-69
  6. Z. Mészáros, D. Borcsiczky, M. Máté, J. Tarcali, K. Tekes, K. Magyar
    Pages 79-85
  7. O. Yu. Abakumova, O. V. Podobed, T. A. Tsvetkova, I. V. Yakusheva, T. A. Moskvitina, L. I. Kondakova et al.
    Pages 87-91
  8. J. Ekblom, H. Garpenstrand, O. Tottmar, J. A. Prince, L. Oreland
    Pages 93-98
  9. K. Magyar, B. Szende, J. Lengyel, J. Tarczali, I. Szatmáry
    Pages 109-123
  10. R. R. Ramsay
    Pages 139-147
  11. J. G. Richards, J. Saura, J. M. Luque, A. M. Cesura, J. Gottowik, P. Malherbe et al.
    Pages 173-187

About these proceedings

Introduction

Monoamine oxidase (MAO) is linked to psychiatric and neurological disorders, because inhibitors of the enzyme are used clinically for treatment of affective disorders and Parkinson’s disease. One of the interesting new aspects of MAO is the occurrence in the human population of deletions of genes coding for one or the other enzyme subtype (A or B). This leads to the possibility of a genetic basis for psychiatric disorders based on MAO. Subjects with deletions of type A or B, and combined deletions, have been described. In the first group of 6 papers in this book, the occurrence and characterization of these phenotypes, as well as the structure of MAO genes, is explored. Advances in the biochemistry of MAO subtypes and their physiological function and localization in brain and periphery is included. Other sections of the book deal with the neuroprotective action of MAO inhibitors and their pharmacology, especially the pharmacology of new MAO-B inhibitors.

Keywords

MAO Monoamine Oxidase Parkinson's Disease affective disorder inhibitor biochemistry brain cell culture enzyme enzymes metabolism mitochondria Oxidation Parkinson Parkinson's disease pathophysiology pharmacology physiology protein receptor

Editors and affiliations

  • J. P. M. Finberg
    • 1
  • M. B. H. Youdim
    • 1
  • P. Riederer
    • 2
  • K. F. Tipton
    • 3
  1. 1.Department of Pharmacology, The Bruce Rappaport Faculty of MedicineTechnion — Israel Institute of TechnologyHaifaIsrael
  2. 2.Clinical Neurochemistry, Department of PsychiatryUniversity of WürzburgFederal Republic of Germany
  3. 3.Biochemistry DepartmentTrinity CollegeDublinIreland

Bibliographic information

  • Book Title MAO — The Mother of all Amine Oxidases
  • Editors John P.M. Finberg
    Moussa B.H. Youdim
    Peter Riederer
    K.F. Tipton
  • Series Title Journal of Neural Transmission. Supplement
  • DOI https://doi.org/10.1007/978-3-7091-6499-0
  • Copyright Information Springer-Verlag/Wien 1998
  • Publisher Name Springer, Vienna
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-211-83038-3
  • Softcover ISBN 978-3-211-83037-6
  • eBook ISBN 978-3-7091-6499-0
  • Series ISSN 0303-6995
  • Edition Number 1
  • Number of Pages XIX, 355
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Additional Information Special edition of Journal of Neural Transmission, Suppl. 52
  • Topics Neurology
    Psychiatry
    Neurosciences
    Pharmacology/Toxicology
    Biochemistry, general
  • Buy this book on publisher's site
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Reviews

"... the book is of particular value and a rich source of information for basic neuroscientists in the field. But it also can be of substantial interest to the rest of the neuroscientific community to get a glimpse of the current status of research in the field of MAO.” Acta Neurologica Belgica