Molecular Machines Involved in Peroxisome Biogenesis and Maintenance

  • Cecile Brocard
  • Andreas Hartig

Table of contents

  1. Front Matter
    Pages i-xv
  2. Peroxisome Biogenesis and Function

    1. Front Matter
      Pages 1-1
    2. Wilhelm Just, Wolf-H. Kunau
      Pages 3-15
    3. Myriam Baes, Simon Verheijden, Paul P. Van Veldhoven
      Pages 17-36
  3. Peroxisomal Diseases

    1. Front Matter
      Pages 61-61
    2. Y. Fujiki, K. Okumoto, S. Mukai, S. Tamura
      Pages 91-110
    3. Michael Schrader, Inês Castro, H. Dariush Fahimi, Markus Islinger
      Pages 125-151
  4. New Technologies Applied to Study Peroxisomes

    1. Front Matter
      Pages 185-185
    2. Kiah A. Barton, Erica-Ashley Jaipargas, Nigel Griffiths, Jaideep Mathur
      Pages 233-253
    3. Bo Wang, Oksana Apanasets, Marcus Nordgren, Marc Fransen
      Pages 255-273
    4. Silke Oeljeklaus, Andreas Schummer, Bettina Warscheid
      Pages 275-301
  5. Protein Transport Across the Peroxisomal Membrane

    1. Front Matter
      Pages 303-303
    2. Daniel Effelsberg, Ralf Erdmann, Wolfgang Schliebs
      Pages 305-323
    3. Bonnie Bartel, Sarah E. Burkhart, Wendell A. Fleming
      Pages 325-345
    4. Harald W. Platta, Stefanie Hagen, Ralf Erdmann
      Pages 347-370

About this book

Introduction

In eukaryotes, lipid metabolism requires the function of peroxisomes. These multitasking organelles are also part of species-specific pathways such as the glyoxylate cycle in yeast and plants or the synthesis of ether lipid in mammals. Proteins required for the biogenesis of peroxisomes typically assemble in large molecular complexes, which participate in membrane formation, protein transport, peroxisome duplication and - inheritance during cell division. Peroxisomal function is essential for life. Mutations in PEX genes, encoding for biogenesis factors, are often associated with lethal disorders. The association of peroxisomes with other organelles suggests an extensive participation in organellar crosstalk. This book represents a state-of-the-art review in the field of peroxisome research encompassing the cell and molecular biology of peroxisome biogenesis and its diseases, the protein complexes involved in this process and the modern technologies applied to study them. The book is intended for graduate students, researchers and lecturers in biochemistry, molecular and cell biology with a biomedical background.

Keywords

Molecular Complex Organelle Biogenesis Organelle Fission Organelle Inheritance Peroxisome Protein Trafficking

Editors and affiliations

  • Cecile Brocard
    • 1
  • Andreas Hartig
    • 2
  1. 1.MauerbachAustria
  2. 2.Max F. Perutz Laboratories University of ViennaViennaAustria

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-7091-1788-0
  • Copyright Information Springer-Verlag Wien 2014
  • Publisher Name Springer, Vienna
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-7091-1787-3
  • Online ISBN 978-3-7091-1788-0
  • About this book
Industry Sectors
Biotechnology
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Pharma