Metabolism of Human Diseases

Organ Physiology and Pathophysiology

  • Eckhard Lammert
  • Martin Zeeb

Table of contents

  1. Front Matter
    Pages i-ix
  2. Martin Zeeb, Eckhard Lammert
    Pages 1-2
  3. Brain

    1. Front Matter
      Pages 3-3
    2. Lorraine V. Kalia
      Pages 5-10
    3. Donatella Marazziti, Grazia Rutigliano, Stefano Baroni, Liliana Dell’Osso
      Pages 11-16
    4. Peter F. Buckley, Adriana Foster
      Pages 17-22
    5. Wesley Plinke, Detlev Boison
      Pages 23-27
    6. Giulia Ambrosi, Silvia Cerri, Fabio Blandini
      Pages 29-33
    7. Milos D. Ikonomovic, Steven T. DeKosky
      Pages 35-40
    8. Massimo Leone, Paola Di Fiore
      Pages 41-45
    9. Markus Kipp
      Pages 47-52
    10. Maria D. Torres, Jorge Busciglio
      Pages 53-56
  4. Eye

    1. Front Matter
      Pages 57-57
    2. Anja Mataruga, Frank Müller
      Pages 59-65
    3. Monika Fleckenstein, Frank G. Holz
      Pages 67-72
    4. Samuel D. Crish, Christine M. Dengler-Crish
      Pages 73-77
  5. Teeth and Bones

    1. Front Matter
      Pages 79-79
    2. Kazuhiko Kawasaki, Kenneth M. Weiss
      Pages 81-85
    3. Colin Robinson
      Pages 87-92
    4. Emmanuel Biver, René Rizzoli
      Pages 93-98
  6. Joints

    1. Front Matter
      Pages 99-99
    2. Jessica Bertrand, Jan Hubert
      Pages 101-106
    3. Camille Roubille, Johanne Martel-Pelletier, Jean-Pierre Pelletier
      Pages 107-113
    4. Marianna Meroni, Elena Bernero, Maurizio Cutolo
      Pages 115-120
  7. Gastrointestinal Tract

    1. Front Matter
      Pages 121-121
    2. Satish Keshav, Philip Allan
      Pages 123-128
    3. Peter C. Konturek, Stanislaw J. Konturek
      Pages 129-135
    4. Christina Quigley, Xi Jiang
      Pages 137-142
    5. Anthony K. Campbell, Stephanie B. Matthews
      Pages 143-148
    6. Kishore Vipperla, Stephen J. O’Keefe
      Pages 149-154
  8. Pancreas

    1. Front Matter
      Pages 155-155
    2. Alexandra E. Folias, Matthias Hebrok
      Pages 157-162
    3. Alena Welters, Eckhard Lammert
      Pages 163-169
  9. Liver

    1. Front Matter
      Pages 171-171
    2. Dieter Häussinger
      Pages 173-179
    3. Matteo Rosselli, Massimo Pinzani
      Pages 181-187
  10. Fat Tissue

    1. Front Matter
      Pages 189-189
    2. Gabriele Schoiswohl, Jules Aljammal, Erin E. Kershaw
      Pages 191-197
    3. Kana Inoue, Norikazu Maeda, Tohru Funahashi
      Pages 199-203
  11. Lung

    1. Front Matter
      Pages 205-205
    2. Martin Zeeb, Andreas Schnapp, Michael-Paul Pieper
      Pages 207-213
    3. Kenji Izuhara, Shoichi Suzuki, Kazuhiko Arima, Shoichiro Ohta, Masako Inamitsu, Ken-ichi Yamamoto
      Pages 215-219
    4. Irena Konstantinova, Andrew C. Pearce
      Pages 221-226
    5. Salvador Sialer, Leonardo F. Difrancesco, Teresa Foix Fabregas, Antoni Torres
      Pages 227-231
  12. Heart

    1. Front Matter
      Pages 233-233
    2. Axel Gödecke
      Pages 235-242
    3. Massimo Slavich, Juan Carlos Kaski
      Pages 243-249
    4. Roman Pfister, Erland Erdmann
      Pages 251-257
  13. Blood Vessels

    1. Front Matter
      Pages 259-259
    2. Victor W. M. van Hinsbergh, Rick Meijer, Etto C. Eringa
      Pages 261-266

About this book


Metabolism of Human Diseases” examines the physiology of key organs (e.g. brain, eye, lung, heart, blood vessels, blood, immune system, gastrointestinal tract, pancreas, liver, fat tissue, kidney, reproductive system, teeth, bone and joints) and how defective metabolism and signaling pathways within these organs contribute to common human diseases. The latter include depression, schizophrenia, epilepsy, Parkinson's disease, Alzheimer's disease, migraine, multiple sclerosis, Down syndrome, macular degeneration, glaucoma, asthma, COPD, pneumonia, atherosclerotic heart disease, heart failure, stroke, varicose veins, Sickle cell disease, hyperlipidemia, fever, sepsis, allergies, peptic ulcer, gastroenteritis, lactose intolerance, colon cancer, diabetes, cirrhosis, metabolic syndrome, hypertension, chronic kidney disease, gout, urinary tract infections, kidney stones, dental caries, osteoporosis, osteoarthritis, rheumatoid arthritis, breast cancer and prostate cancer. The book also describes commonly used drugs and explains their molecular targets. It provides the first comprehensive and detailed summary of the metabolism of individual organs and their physiological and pathological functioning. Thus it serves as a useful supplement to previous textbooks of human physiology. “Metabolism of Human Diseases is a must-have, state-of-the-art textbook written by International experts for graduate students, postdocs and scientists in metabolic research, biochemistry, physiology and pharmacy as well as for physicians interested in molecular mechanisms underlying common human diseases.



biochemical metabolism drug treatment key organs lipid metabolism metabolic diseases pathological metabolic changes physiological consequences physiological functioning

Editors and affiliations

  • Eckhard Lammert
    • 1
  • Martin Zeeb
    • 2
  1. 1.Institute of Metabolic Physiology, German Diabetes CenterHeinrich Heine University DüsseldorfDüsseldorfGermany
  2. 2.CardioMetabolic Diseases ResearchBoehringer Ingelheim Pharma GmbH & Co KGBiberachGermany

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