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© 2010

Clinical Pharmacology: Current Topics and Case Studies

  • Markus Müller
Book
  • 64k Downloads

Table of contents

  1. Front Matter
    Pages I-XXIV
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Markus Müller
      Pages 3-6
    3. Markus Müller
      Pages 7-18
    4. Marcus Müllner, Hans-Georg Eichler
      Pages 19-31
    5. Anna Bucsics
      Pages 33-50
  3. Clinical Trials

    1. Front Matter
      Pages 51-51
    2. Ernst Singer, Christiane Druml
      Pages 53-61
    3. Brigitte Bloechl-Daum, Christiane Druml
      Pages 63-87
    4. Ulla Derhaschnig, Bernd Jilma
      Pages 89-99
    5. Michael Wolzt, Stefan Aschauer
      Pages 101-111
    6. Harald Herkner, Christoph Male
      Pages 113-141
    7. Sreedharan N. Sabarinath, Rajendra Pratap Singh, Hartmut Derendorf
      Pages 143-155
    8. Gerhard Garhöfer, Leopold Schmetterer
      Pages 167-180
    9. Magdalena Pilz, Johannes Pleiner
      Pages 181-190
  4. Tools in Clinical Pharmacology

    1. Front Matter
      Pages 191-191
    2. Martin Bauer, Oliver Langer
      Pages 193-203
    3. Volker Wacheck
      Pages 225-239

About this book

Introduction

Today we witness an eventful time in which the powerful new forces of genomics, information technology and economics are rapidly changing the science and art of medicine. This will require more specialization than ever before. However, there is also an increasing demand for an integrated approach, which is provided by the discipline of Clinical Pharmacology (CP). CP pursues a scientific goal by studying drug action in patients and volunteers, a clinical goal by administering appropriate drug therapy and a regulatory goal by assessing the risk/benefit ratio of drug candidates in drug development and reimbursement. This introduction to current topics of CP covers traditional topics of clinical drug research and trial methodology but also provides insight in current topics like genomics, imaging technology and issues in drug reimbursement. A number of concrete case studies in clinical drug research and development help to give a better understanding of the general principles of CP.

Keywords

Alzheimer clinical research clinical trial drug drug development drug research ethics gene therapy kinetics pharmacodynamics pharmacokinetics pharmacology research siRNA vaccine

Editors and affiliations

  • Markus Müller
    • 1
  1. 1.Department of Clinical PharmacologyMedical University Vienna, Vienna General Hospital (AKH)ViennaAustria

About the editors

Markus Müller, MD, born August 23, 1967 is a board certified specialist in Internal Medicine and Clinical Pharmacology. He has been trained in Austria, Sweden and the US and currently serves as tenured, full Professor and Head of the Department of Clinical Pharmacology of the Vienna Medical University at the Vienna General Hospital (AKH). He is responsible for ~ 80 staff members. The Department is specialized on clinical research in a wide variety of therapeutic areas and on the development of novel drugs in close collaboration with the pharmaceutical industry. Prof Müller serves on numerous national and international boards (e.g. council member of the European Association for Clinical Pharmacology and Therapeutics; Chairman of the Pharmacological Expert Committee, Association of Austrian Social Insurance Institutions; European Expert, European Medicines Agency (EMEA), London, UK; adjunct faculty member University of Florida, USA). He has also served as chairman of an FDA workshop and is a delegate of the Standing Committee of the European Medical Research Council. Prof. Müller is (Co) Inventor of 2 patents and has received several awards, e.g. the 2004 Tanabe Award of the American College of Clinical Pharmacology (ACCP) in acknowledgement of innovations in clinical pharmacology trials. He is deputy editor of the International Journal of Clinical Pharmacology and Therapeutics and reviewer for numerous scientific journals. He has published > 170 peer reviewed articles, e.g. in the New England Journal of Medicine, Nature Medicine or the British Medical Journal.

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