Management of Periprosthetic Joint Infection

A global perspective on diagnosis, treatment options, prevention strategies and their economic impact

  • Klaus-Dieter Kühn

Table of contents

  1. Front Matter
    Pages I-XVIII
  2. Klaus-Dieter Kühn
    Pages 1-4
  3. Klaus-Dieter Kühn
    Pages 5-24
  4. Klaus-Dieter Kühn
    Pages 25-42
  5. Klaus-Dieter Kühn
    Pages 43-75
  6. Klaus-Dieter Kühn
    Pages 77-126
  7. Klaus-Dieter Kühn
    Pages 127-213
  8. Klaus-Dieter Kühn
    Pages 215-255
  9. Klaus-Dieter Kühn
    Pages 257-309
  10. Klaus-Dieter Kühn
    Pages 311-357
  11. Back Matter
    Pages 359-366

About this book


Periprosthetic joint infection (PJI) is among the most serious complications in the field of endoprosthetics. The number of PJIs is increasing worldwide and poses a real interdisciplinary challenge for everyone involved. For the patient concerned, it is necessary to promptly work out an adequate therapy solution to fight off the infection. Both the clinical experience of the surgeon and the proper diagnostic processes are prerequisite for the reliable detection and identification of an infection. The microbiologist is responsible for identifying the causative germs by screening the patient’s synovial fluid and tissue samples. Based on the findings and subsequent resistance testing, the infectious disease specialist can recommend the appropriate antibiotic therapy. Furthermore, the clinical pharmacist is consulted regularly throughout the therapy to discuss the risk of potential drug interactions. The surgeon will proceed with the revision surgery, following defined algorithms. Adequate radical debridement of infected and necrotic surrounding tissue is the most important step towards a successful cure of the infection. Accompanying the surgery, anti-infective agents are given systemically and locally. While systemic application of anti-infectives mainly reduces the number of haematogenic-spreading planktonic germs, local application immediately forms a colonization barrier and protects the implant from sessile biofilm formation. Concurrently, antibiotics are actively released from the implant, resulting in local germ reduction. Thus, local agents are embedded in the concept of surgical PJI treatment as a reliable adjuvant measure and they sustainably support the successful outcome. In one-stage procedures, local agents are released from specialized antibiotic-loaded bone cements, while in two- or multi-stage procedures, local agents are released from corresponding temporary spacers (interim prostheses). Even from an economic standpoint, the combination of systemic and local agent application is meaningful. Furthermore, there are some interesting trends towards the coating of metallic implants to protect against biofilm formation on the implant surface.

On the basis of their personal experience, specialists from all over the world present, explain and discuss preventive approaches, appropriate diagnostic strategies for detection, reproducible effective surgical treatments  as well as the economic impact of PJI. The reader can use this book as a solid platform for comparing their own approach to PJI treatment with the specialists’ recommendations.  


Treatment of Orthopedic Septic Revisions Bone Cements PMMA Joint Replacement Antibiotics

Editors and affiliations

  • Klaus-Dieter Kühn
    • 1
  1. 1.Department of Orthopaedic SurgeryMedical University GrazGrazAustria

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag GmbH Germany 2018
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-662-54468-6
  • Online ISBN 978-3-662-54469-3
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals