Orofacial Pain Biomarkers

  • Jean-Paul Goulet
  • Ana Miriam Velly

Table of contents

  1. Front Matter
    Pages i-x
  2. Clinical and Epidemiological Aspects of Orofacial Pain

    1. Front Matter
      Pages 1-1
  3. Mechanisms of Chronic Orofacial Pain

    1. Front Matter
      Pages 33-33
    2. Laurence Bourgeais Rambur, Charles-Daniel Arreto, Claude Robert, Luis Villanueva
      Pages 47-61
  4. Biomarkers in Orofacial Pain

    1. Front Matter
      Pages 63-63
    2. Satu K. Jääskeläinen
      Pages 65-77
    3. Malin Ernberg
      Pages 79-93
    4. Ze’ev Seltzer, Scott R. Diehl
      Pages 107-118
    5. Stergios Katsiougiannis, Varun R. Mallela, Christopher A. Schafer, David T. W. Wong
      Pages 119-131
  5. Study Designs and Statistical Analysis for the Identification of Biomarkers,and Future Direction

    1. Front Matter
      Pages 133-133
    2. Ana Miriam Velly, Shrisha Mohit, Hyman M. Schipper, Mervyn Gornitsky
      Pages 135-139
    3. Jean-Paul Goulet, Ana Miriam Velly
      Pages 147-150
  6. Back Matter
    Pages 151-155

About this book


This book provides up-to-date information on all aspects of orofacial pain biomarkers. It opens by presenting background information on clinical phenotypes and the neurobiological substrates underlying chronic orofacial pain and by explaining the potential role of biomarkers in the diagnosis, prognostic evaluation, and treatment of orofacial pain. The main section of the book examines the contribution of human and animal studies to the field of biomarkers for orofacial pain and discusses biomarkers for masticatory muscle pain, temporomandibular joint pain, neuropathic face pain, and autonomic nervous system involvement in trigeminal facial pain. The potential impacts of the immune system on orofacial pain biomarkers and candidate gene phenotypes with possible links to chronic orofacial pain conditions are also addressed, and differences and similarities between saliva and serum biomarkers for pain are explained as well. The final section covers research-related issues in assessment methods and statistical analyses used in evaluating biomarkers, identifies future challenges and suggests new directions in the field.


Chronic Pain Neuropathologic Biomarkers Saliva Biomarkers Serum Biomarkers Temporomandibular Disorders Trigeminal Face Pain

Editors and affiliations

  • Jean-Paul Goulet
    • 1
  • Ana Miriam Velly
    • 2
  1. 1.Faculté de médecine dentaireUniversité LavalQuébecCanada
  2. 2.Faculty of DentistryMcGill University, Department of Dentistry of Jewish General HospitalMontréalCanada

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag GmbH Germany 2017
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-662-53992-7
  • Online ISBN 978-3-662-53994-1
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals