© 2017

Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin

Methodology and General Considerations

  • Nina Dragicevic
  • Howard I. Maibach

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Factors Influencing Percutaneous Drug Penetration

    1. Front Matter
      Pages 1-1
    2. Dominik Selzer, Ulrich F. Schaefer, Claus-Michael Lehr, Steffi Hansen
      Pages 3-25
    3. Wing Man Lau, Keng Wooi Ng
      Pages 35-44
    4. Jeffrey E. Grice, Hamid R. Moghimi, Elizabeth Ryan, Qian Zhang, Isha Haridass, Yousuf Mohammed et al.
      Pages 45-75
    5. V. R. Leite-Silva, Jeffrey E. Grice, Yousuf Mohammed, Hamid R. Moghimi, Michael S. Roberts
      Pages 77-93
    6. S. Kevin Li, William I. Higuchi
      Pages 119-136
  3. Methods for Measuring the Percutaneous Drug Penetration

    1. Front Matter
      Pages 151-151
    2. Donald M. Cropek, Pankaj Karande
      Pages 153-184
    3. Ulrich F. Schaefer, D. Selzer, S. Hansen, Claus-Michael Lehr
      Pages 185-203
    4. Jürgen Lademann, Sabine Schanzer, Heike Richter, Martina C. Meinke, Hans-Jürgen Weigmann, Alexa Patzelt
      Pages 205-214
    5. Stéphanie Briançon, Marie-Alexandrine Bolzinger, Yves Chevalier
      Pages 229-246
    6. Julia Covi-Schwarz, Victoria Klang, Claudia Valenta
      Pages 247-254
    7. Mukul A. Ashtikar, Daya D. Verma, Alfred Fahr
      Pages 255-281
    8. Claudine Piérard-Franchimont, Trinh Hermanns-Lê, Gérald E. Piérard
      Pages 303-307

About this book


Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered, and the latest findings are provided on skin structure and function, mathematics in skin permeation, and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners, students and dermatological scientists or dermatologists​.


Assessment of drug penetration enhancement Enhancement techniques Retardation of percutaneous penetration Skin permeation Transdermal drug delivery

Editors and affiliations

  • Nina Dragicevic
    • 1
  • Howard I. Maibach
    • 2
  1. 1.Apoteka “Beograd”BelgradeSerbia
  2. 2.San FranciscoUSA

About the editors

Howard I. Maibach is Professor of Dermatology at the University of California, San Francisco. He is a leading authority in the fields of dermatotoxicology and dermatopharmacology, in which he has conducted much original research and written very extensively, with a total of more than 2,500 publications as lead or co-author. Professor Maibach has served on the editorial boards of more than 30 scientific journals and is a member of many professional societies, including the American Academy of Dermatology and the International Commission on Occupational Health. He has also been the recipient of numerous honors, both within the United States and overseas. Nina Dragićević-Ćurić graduated from the University of Belgrade, Faculty of Pharmacy in 1999 and subsequently obtained an MSc and a PhD (summa cum laude, Dr. rer. nat.) in Pharmaceutical Technology from the University of Belgrade and the Friedrich-Schiller University, Jena, respectively. Dr. Dragićević-Ćurić is an accredited Specialist in Pharmaceutical Technology. Since 2007 she has been responsible for the preparation of compounded drugs in pharmacies of the state pharmaceutical company “Apoteka Beograd” in Belgrade. She has published in a variety of international journals.

Bibliographic information

  • Book Title Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin
  • Book Subtitle Methodology and General Considerations
  • Editors Nina Dragicevic
    Howard I. Maibach
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2017
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-662-53268-3
  • Softcover ISBN 978-3-662-57123-1
  • eBook ISBN 978-3-662-53270-6
  • Edition Number 1
  • Number of Pages XVI, 414
  • Number of Illustrations 76 b/w illustrations, 50 illustrations in colour
  • Topics Dermatology
  • Buy this book on publisher's site
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