Principles of Safety Pharmacology

  • Michael K. Pugsley
  • Michael J Curtis

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 229)

Table of contents

  1. Front Matter
    Pages i-viii
  2. An Overview of Safety Pharmacology and Its Role in Drug Discovery

    1. Front Matter
      Pages 1-1
    2. Alan S. Bass, Toshiyasu Hombo, Chieko Kasai, Lewis B. Kinter, Jean-Pierre Valentin
      Pages 3-45
    3. Bruce H. Morimoto, Erin Castelloe, Anthony W. Fox
      Pages 65-80
  3. The Safety Pharmacology Core Battery

  4. Supplemental Safety Pharmacology

    1. Front Matter
      Pages 265-265
    2. Matthew M. Abernathy
      Pages 267-290
    3. Ahmad Al-Saffar, André Nogueira da Costa, Annie Delaunois, Derek J. Leishman, Louise Marks, Marie-Luce Rosseels et al.
      Pages 291-321
    4. Amanda Benjamin, Andre Nogueira da Costa, Annie Delaunois, Marie-Luce Rosseels, Jean-Pierre Valentin
      Pages 323-352
  5. Safety Pharmacology of Biological and Anticancer Pharmaceuticals

    1. Front Matter
      Pages 383-383
    2. Hamid R. Amouzadeh, Michael J. Engwall, Hugo M. Vargas
      Pages 385-404
    3. Pauline L. Martin
      Pages 405-431
  6. Clinical Safety Pharmacology

    1. Front Matter
      Pages 433-433
    2. Borje Darpo
      Pages 435-468
  7. Back Matter
    Pages 469-481

About this book


This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.


Biologics Drug Discovery Pharmacokinetics Risk Assessment Safety Pharmacology

Editors and affiliations

  • Michael K. Pugsley
    • 1
  • Michael J Curtis
    • 2
  1. 1.Drug Safety SciencesJohnson & Johnson PR&DRaritanUSA
  2. 2.Cardiovascular Division, Faculty of Life Sciences & Medicine, St Thomas' HospitalKing's College London, Rayne InstituteLondonUnited Kingdom

Bibliographic information

Industry Sectors
Health & Hospitals
Consumer Packaged Goods