© 2015

Advances in Metallic Biomaterials

Tissues, Materials and Biological Reactions

  • Mitsuo Niinomi
  • Takayuki Narushima
  • Masaaki Nakai

Part of the Springer Series in Biomaterials Science and Engineering book series (SSBSE, volume 3)

Table of contents

  1. Front Matter
    Pages i-x
  2. Biological Tissues and Organs

    1. Front Matter
      Pages 1-1
    2. Reed A. Ayers, Evalina Levina Burger, Christopher J. Kleck, Vikas Patel
      Pages 53-70
    3. Takeo Matsumoto, Shukei Sugita, Toshiyuki Yaguchi
      Pages 71-98
    4. Shinji Kamakura
      Pages 99-122
  3. Metallic Biomaterials

    1. Front Matter
      Pages 123-123
    2. Yasuyuki Katada, Tetsushi Taguchi
      Pages 125-156
    3. Takayuki Narushima, Kyosuke Ueda, Alfirano
      Pages 157-178
    4. Mitsuo Niinomi, Carl J. Boehlert
      Pages 179-213
    5. Naoyuki Nomura
      Pages 215-221
    6. Barry O’Brien
      Pages 245-272
  4. Reactions of Metals in Human Body

    1. Front Matter
      Pages 273-273
    2. Burak Dikici, Ziya Esen, Ozgur Duygulu, Serap Gungor
      Pages 275-303
    3. Mitsuko Kawano, Yuri Takeda, Kouetsu Ogasawara
      Pages 305-321
    4. Akiko Obata, Toshihiro Kasuga
      Pages 323-348

About this book


This book reviews fundamental advances in the use of metallic biomaterials to reconstruct hard tissues and blood vessels. It also covers the latest advances in representative metallic biomaterials, such as stainless steels, Co-Cr alloys, titanium and its alloys, zirconium, tantalum and niobium based alloys. In addition, the latest findings on corrosion, cytotoxic and allergic problems caused by metallic biomaterials are introduced. The book offers a valuable reference source for researchers, graduate students and clinicians working in the fields of materials, surgery, dentistry, and mechanics.

Mitsuo Niinomi, PhD, D.D.Sc., is a Professor at the Institute for Materials Research, Tohoku University, Japan

Takayuki Narushima, PhD, is a Professor at the Department of Materials Processing, Tohoku University, Japan

Masaaki Nakai, PhD, is an Associate Professor at the Institute for Materials Research, Tohoku University, Japan


Biological tissues and organs Corrosion of metallic biomaterials Cyto-toxicity Metal alloys Metallic allergy Nickel-free high nitrogen stainless steel Orthopaedic surgery Porous tantalum Spinal instrumentation Tooth-supporting structures

Editors and affiliations

  • Mitsuo Niinomi
    • 1
  • Takayuki Narushima
    • 2
  • Masaaki Nakai
    • 3
  1. 1.Institute for Materials ResearchTohoku UniversitySendaiJapan
  2. 2.Department of Materials ProcessingTohoku UniversitySendaiJapan
  3. 3.Institute for Materials ResearchTohoku UniversitySendaiJapan

About the editors

Prof. Mitsuo Niinomi earned his Ph.D. degree from the Department of Metallurgical Engineering, and Steel and Iron Engineering, Nagoya University in 1980, and his D.D.Sc. from the Department of Dentistry, Aichi-Gakuin University in 2003. From 1980 to 2005, he was a Research Associate, Associate Professor, and Professor at Toyohashi University of Technology. In 2005, he moved to the Institute for Materials Research, Tohoku University as a Professor, and he was elected as the director of this institute in 2009. He was a visiting Associate Professor at Carnegie-Mellon University (USA) from July 1988 to June 1989, a visiting Professor at The University of Dayton (USA) and a foreign researcher at Wright Patterson Air Force Base, US Air Force from July 1997 to December 1997. He was appointed as an honorary Professor of Tianjin University, China from 2011, and a visiting Professor of Northeastern University, China from 2010-2015. He has been working in the area of fracture and microstructure relations of materials with a focus on titanium alloys for structural and biomedical applications. His recent research focuses on the design, development, and evaluation of biological and mechanical biocompatibility of titanium alloys for medical and dental applications.

Prof. Takayuki Narushima received his B.S., M.S., and Ph.D. degrees in Engineering from Tohoku University, Japan, in 1985, 1987, and 1994, respectively. He joined the Department of Metallurgy at Tohoku University as a Research Associate from 1987 to 1994 and as an Associate Professor from 1994 to 2004. He was a Professor in the Tohoku University Biomedical Engineering Research Organization (TUBERO) and has been a Professor at the Department of Materials Processing at Tohoku University since 2007. From 1998 to 1999, he was a Research Fellow at the University of California, Berkeley (Monbusyo Fellowship Program). His current research interests include precipitation control in biomedical Co-Cr alloys and Ni-Ti alloys, calcium phosphate coating on titanium, photocatalytic activity of oxide layers on titanium, and in vivo reactions of metallic materials.

Prof. Masaaki Nakai is an Associate Professor at the Institute for Materials Research, Tohoku University. He received his Ph.D. degree from Nagoya University in 2005. From 2005 to 2006, he was a Research Fellow of the Japan Society for the Promotion of Science (JSPS). Then, he was a Research Associate and an Assistant Professor at the Institute for Materials Research, Tohoku University. His research mainly focuses on the development of titanium alloys for biomedical applications.

Bibliographic information

  • Book Title Advances in Metallic Biomaterials
  • Book Subtitle Tissues, Materials and Biological Reactions
  • Editors Mitsuo Niinomi
    Takayuki Narushima
    Masaaki Nakai
  • Series Title Springer Series in Biomaterials Science and Engineering
  • Series Abbreviated Title Springer Ser. Biomaterials Sci., Engineer.
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2015
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Chemistry and Materials Science Chemistry and Material Science (R0)
  • Hardcover ISBN 978-3-662-46835-7
  • Softcover ISBN 978-3-662-52452-7
  • eBook ISBN 978-3-662-46836-4
  • Series ISSN 2195-0644
  • Series E-ISSN 2195-0652
  • Edition Number 1
  • Number of Pages X, 348
  • Number of Illustrations 149 b/w illustrations, 31 illustrations in colour
  • Topics Biomaterials
    Biomedical Engineering and Bioengineering
    Metallic Materials
  • Buy this book on publisher's site
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Chemical Manufacturing