© 2014

Renal Tumors of Childhood

Biology and Therapy

  • Kathy Pritchard-Jones
  • Jeffrey S. Dome
  • Integrates state of the art information on biological advances and clinical dilemmas in a format that will be easily understandable for practising clinicians and research scientists

  • Documents the recent explosion in knowledge of molecular changes in the various childhood renal tumours

  • Details the different treatment approaches and discusses the incorporation of biologically targeted agents into front-line therapy


Part of the Pediatric Oncology book series (PEDIATRICO)

Table of contents

  1. Front Matter
    Pages i-x
  2. Charles A. Stiller, Andrew F. Olshan
    Pages 1-17
  3. Richard H. Scott, Nazneen Rahman
    Pages 19-38
  4. Elizabeth Mullen, Norbert Graf
    Pages 39-52
  5. Gordan M. Vujanic
    Pages 53-76
  6. Rhoikos Furtwängler, Kathy Pritchard-Jones
    Pages 101-118
  7. Filippo Spreafico, Marcio H. Malogolowkin
    Pages 119-131
  8. Geetika Khanna, Øystein E. Olsen
    Pages 133-152
  9. Kathy Pritchard-Jones, Mariana Maschietto, Paul Grundy
    Pages 153-166
  10. James I. Geller, Peter Hohenstein
    Pages 167-186
  11. Mark N. Gaze, John A. Kalapurakal
    Pages 207-227
  12. Gill A. Levitt, Daniel M. Green
    Pages 229-247
  13. Jeffrey S. Dome, Saskia L. Gooskens, M. M. van den Heuvel-Eibrink
    Pages 249-269
  14. Monika Metzger, Judith A. Wilimas, Mhamed Harif, Trijn Israels
    Pages 271-281

About this book


This book provides a comprehensive overview of the biological basis of renal tumors in childhood and the clinical approaches to their treatment. Recent advances in our understanding of the molecular genetics of Wilms and other renal tumors are placed in their clinical context, including the differing treatment approaches of immediate surgery or pre-operative chemotherapy. The challenges in applying this knowledge to improve risk stratification and to incorporate biologically targeted agents into front-line therapy are discussed. In addition, the current state of thinking of the two major clinical trial groups in these diseases is presented. All of the authors are experts from Europe and North America, and the book has been written specifically as an easy reference for the practising clinician and the research scientist. It lays the basis for understanding the future direction of clinical and translational research to improve outcomes in patients with childhood renal tumors and will prove indispensable for those treating or researching into these diseases.


Childhood Cancer Kidney Nephroblastomatosis Wilms Tumours

Editors and affiliations

  • Kathy Pritchard-Jones
    • 1
  • Jeffrey S. Dome
    • 2
  1. 1.Department of Developmental Biology and CancerInstitute of Child Health, University College LondonLondonUnited Kingdom
  2. 2.Children's National Medical Center Center for Cancer & Blood DisordersWashingtonUSA

Bibliographic information

  • Book Title Renal Tumors of Childhood
  • Book Subtitle Biology and Therapy
  • Editors Kathy Pritchard-Jones
    Jeffrey S. Dome
  • Series Title Pediatric Oncology
  • Series Abbreviated Title Pediatric Oncology
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-662-44002-5
  • Softcover ISBN 978-3-662-51918-9
  • eBook ISBN 978-3-662-44003-2
  • Series ISSN 1613-5318
  • Series E-ISSN 2191-0812
  • Edition Number 1
  • Number of Pages X, 281
  • Number of Illustrations 25 b/w illustrations, 55 illustrations in colour
  • Topics Oncology
    Surgical Oncology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Oncology & Hematology