© 2014

Reducing Drug Attrition

  • James R. Empfield
  • Michael P Clark


  • Overview chapters introduce the newcomer to the topic covered

  • Series covers hot topics of frontier research summarized by reputed scientists in the field

  • Volumes are useful and of relevance for a long period of time


Part of the Topics in Medicinal Chemistry book series (TMC, volume 11)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Douglas K. Spracklin, Amit S. Kalgutkar, Angus N. R. Nedderman
    Pages 97-137
  3. Back Matter
    Pages 159-162

About this book


Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Editors and affiliations

  • James R. Empfield
    • 1
  • Michael P Clark
    • 2
  1. 1.Vertex PharmaceuticalsBostonUSA
  2. 2.Vertex PharmaceuticalsBostonUSA

Bibliographic information

  • Book Title Reducing Drug Attrition
  • Editors James R. Empfield
    Michael P Clark
  • Series Title Topics in Medicinal Chemistry
  • Series Abbreviated Title Topics Medicinal Chemistry
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Chemistry and Materials Science Chemistry and Material Science (R0)
  • Hardcover ISBN 978-3-662-43913-5
  • Softcover ISBN 978-3-662-50567-0
  • eBook ISBN 978-3-662-43914-2
  • Series ISSN 1862-2461
  • Series E-ISSN 1862-247X
  • Edition Number 1
  • Number of Pages XV, 162
  • Number of Illustrations 16 b/w illustrations, 6 illustrations in colour
  • Topics Medicinal Chemistry
  • Buy this book on publisher's site
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