© 2014

Upscaling of Bio-Nano-Processes

Selective Bioseparation by Magnetic Particles

  • Hermann Nirschl
  • Karsten Keller


  • Presents solutions for large scale bioprocessing of nanoparticles

  • Suggests a new application for magnetic particles for upscaling of protein separation

  • Addresses toxicological aspects related to food, pharmaceutical and feed industry


Part of the Lecture Notes in Bioengineering book series (LNBE)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Hermann Nirschl
    Pages 1-12
  3. Particle Synthesis and Functionalization

    1. Front Matter
      Pages 13-13
    2. Rodica Turcu, Izabell Craciunescu, Alexandrina Nan
      Pages 57-76
    3. Elisabeth Rondeau, Sebastian Holzapfel, Helen Engel, Erich J. Windhab
      Pages 77-96
    4. Valéry Tchanque Kemtchou, Maria Schäfer, Urs Alexander Peuker
      Pages 97-116
  4. Magnetic Separation Devices

    1. Front Matter
      Pages 129-129
    2. Johannes Lindner, Karsten Keller, Gunnar Grim, Johannes Feller, Christian Fiil Nielsen, Niels Dalgaard et al.
      Pages 131-146
    3. Anja Paulus, Matthias Franzreb
      Pages 175-186
  5. Process Examples

    1. Front Matter
      Pages 187-187
    2. Alexander Scholz, Martin Cerff, Clemens Posten
      Pages 189-211
    3. Christian Fiil Nielsen, Karsten Keller, Susanne Rasmussen, Niels Dalgaard, Timothy John Hobley, Wickie Sondergaard et al.
      Pages 213-233
  6. Conclusion

    1. Front Matter
      Pages 235-235
    2. Johannes Lindner, Karsten Keller, Hermann Nirschl
      Pages 237-241
  7. Back Matter
    Pages 243-245

About this book


Despite ongoing progress in nano- and biomaterial sciences, large scale bioprocessing of nanoparticles remains a great challenge, especially because of the difficulties in removing unwanted elements during processing in food, pharmaceutical and feed industry at production level. This book presents magnetic nanoparticles and a novel technology for the upscaling of protein separation. The results come from the EU Project "MagPro2Life", which was conducted in cooperation of several european institutions and companies.


Bioprocessing of Nanoparticles Food Safety Halbach magnet based HGMS High Gradient Magnetic Separation In-situ Magnetic Separation Laser Pyrolysis Magnetic Microgels Magnetic Particles Scalling up Processing Superparamagnetic Nanoparticles

Editors and affiliations

  • Hermann Nirschl
    • 1
  • Karsten Keller
    • 2
  1. 1.Institute of Mechanical Process Engineering and MechanicsKarlsruhe Institute of TechnologyKarlsruheGermany
  2. 2.DuPontWilmingtonUSA

About the editors

Prof. Dr.-Ing. Hermann Nirschl is head of chair of process machinery at the institute of mechanical process engineering and mechanics at the Karlsruhe Institute of Technology, focusing on process machinery in solid liquid separation, blending, milling, nanoscaled particle structures and numerical simulation.

Dr. Karsten Keller is an Engineering Fellow of the Discovery Research group at Solae LLC (JV of DuPont) and has over 20 years of process engineering experience. He is developing novel processes for protein and new product opportunities from the lab-scale to commercial production and is the author of over 70 publications on subjects of separation, modeling, particle technology, biotechnology and nanotechnology. He is the inventor of 8 patents worldwide.

Bibliographic information

  • Book Title Upscaling of Bio-Nano-Processes
  • Book Subtitle Selective Bioseparation by Magnetic Particles
  • Editors Hermann Nirschl
    Karsten Keller
  • Series Title Lecture Notes in Bioengineering
  • Series Abbreviated Title Lect.Notes Bioengineering
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Engineering Engineering (R0)
  • Hardcover ISBN 978-3-662-43898-5
  • Softcover ISBN 978-3-662-50983-8
  • eBook ISBN 978-3-662-43899-2
  • Series ISSN 2195-271X
  • Series E-ISSN 2195-2728
  • Edition Number 1
  • Number of Pages XVII, 245
  • Number of Illustrations 112 b/w illustrations, 29 illustrations in colour
  • Topics Biotechnology
    Food Science
  • Buy this book on publisher's site
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