Medication-Related Osteonecrosis of the Jaws

Bisphosphonates, Denosumab, and New Agents

  • Sven Otto

Table of contents

  1. Front Matter
    Pages i-viii
  2. Cornelia Then, Emmo von Tresckow, Reiner Bartl, Fuat S. Oduncu
    Pages 17-26
  3. Sven Otto, Tae-Geon Kwon, Alexandre Th. Assaf
    Pages 43-54
  4. Towy Sorel Lazarovici, Tal Yoffe
    Pages 55-61
  5. Florian A. Probst, Monika Probst, Sotirios Bisdas
    Pages 63-77
  6. Paolo Vescovi, Maddalena Manfredi, Elisabetta Merigo
    Pages 103-109
  7. Risa Chaisuparat, Bruno C. Jham
    Pages 131-137
  8. Sven Otto, Jose Ignacio Aguirre, Ezher Dayisoylu, Thomas Ziebart
    Pages 139-148
  9. Noam Yarom, Stefano Fedele
    Pages 149-153
  10. Sebastian Hoefert, Feraydoon Sharghi, Eva Engel
    Pages 169-178
  11. Matthias Troeltzsch, Markus Troeltzsch, Christoph Pache, Timothy Woodlock
    Pages 193-200
  12. Sebastian Hoefert, Claudia Sade Hoefert, Martin Widmann
    Pages 201-205
  13. Ralf Smeets, Henning Hanken, Ole Jung, Max Heiland
    Pages 207-215
  14. Back Matter
    Pages 217-220

About this book


Osteonecrosis of the jaws is a well-known side-effect of antiresorptive therapy that predominantly occurs in patients suffering from malignant diseases and receiving intravenous administrations of nitrogen-containing bisphosphonates or subcutaneous administrations of denosumab, a monoclonal antibody. Less frequently it may also be observed in patients with osteoporosis who are being treated with these antiresorptive drugs. 

This textbook provides detailed, up-to-date information on all aspects of medication-related osteonecrosis of the jaws, including clinical features, pathogenesis, treatment options, and preventive measures. It also explains safe prevention and treatment strategies for patients receiving antiresorptive drugs who require extractions, implant insertions, and other dento-alveolar surgeries. This book will be of major interest for medical and dental students, dentists, and oral and maxillofacial surgeons as well as osteologists and oncologists.


BRONJ Bisphosphonates Denosumab Implants Malignant Diseases Oral Surgery

Editors and affiliations

  • Sven Otto
    • 1
  1. 1.Department of Oral and Maxillofacial SurLudwig-Maximilians-University of MunichMunichGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2015
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-662-43732-2
  • Online ISBN 978-3-662-43733-9
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals