© 2014

Metronomic Chemotherapy

Pharmacology and Clinical Applications

  • Guido Bocci
  • Giulio Francia

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Pharmacological Bases of Metronomic Chemotherapy

  3. Clinical Activity of Metronomic Chemotherapy

    1. Front Matter
      Pages 91-91
    2. Elisabetta Munzone, Francesco Bertolini, Marco Colleoni
      Pages 93-110
    3. Keemo Delos Santos, Lavarnan Sivanathan, Kelly Lien, Urban Emmenegger
      Pages 119-134
    4. Lisa Salvatore, Federica Zoratto, Fotios Loupakis, Alfredo Falcone
      Pages 135-142
    5. Narges Baluch, Sushil Kumar, Reza Mokhtari, Sylvain Baruchel
      Pages 157-172
    6. Pannee Praditsuktavorn, Jia Ruan
      Pages 173-188
    7. Yu-Yun Shao, Ann-Lii Cheng, Chih-Hung Hsu
      Pages 189-202
    8. Victoria A. Forte, Agustin A. Garcia
      Pages 203-216
    9. Athanasios Kotsakis, Nikolaos Kentepozidis, Vassilis Georgoulias
      Pages 217-226
  4. Clinical Pharmacology of Metronomic Chemotherapy

    1. Front Matter
      Pages 227-227
    2. Guido Bocci, Giulio Francia
      Pages 229-246

About this book


This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoenconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.


Antiangiogenic drugs Cancer Metronomic chemotherapy Pharmacology

Editors and affiliations

  • Guido Bocci
    • 1
  • Giulio Francia
    • 2
  1. 1.Division of Pharmacology, Department of Clinical and Experimental MedicineUniversity of PisaPisaItaly
  2. 2.Department of Biological SciencesUniversity of Texas at El PasoEl PasoUSA

Bibliographic information

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