Interleukin-10 in Health and Disease

  • Simon Fillatreau
  • Anne O'Garra

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 380)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Abhisake Kole, Kevin J. Maloy
    Pages 19-38
  3. Maria Grazia Roncarolo, Silvia Gregori, Rosa Bacchetta, Manuela Battaglia
    Pages 39-68
  4. Ellen Hilgenberg, Ping Shen, Van Duc Dang, Stefanie Ries, Imme Sakwa, Simon Fillatreau
    Pages 69-92
  5. Cherie T. Ng, Michael B. A. Oldstone
    Pages 129-144
  6. Susan R. Quinn, Luke A. O’Neill
    Pages 145-155
  7. Leona Gabryšová, Ashleigh Howes, Margarida Saraiva, Anne O’Garra
    Pages 157-190
  8. Celine Eidenschenk, Sascha Rutz, Oliver Liesenfeld, Wenjun Ouyang
    Pages 213-236
  9. Back Matter
    Pages 237-238

About this book


This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date.


Anti-inflammatory cytokine Counter-regulation of immunity IL-10 expression Il-10 polymorphisms Innate microbial recognition Interleukin-10 Intestinal immunity Maintenance of immune homeostasis TLR triggering Tr1 cells Viral IL-10 homologs

Editors and affiliations

  • Simon Fillatreau
    • 1
  • Anne O'Garra
    • 2
  1. 1.Deutsches Rheuma-Forschungszentrum BerlinBerlinGermany
  2. 2.Div. of ImmunoregulationThe MRC National Institute for Medical ResearchLondonUnited Kingdom

Bibliographic information

Industry Sectors
Health & Hospitals