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c-Myc Function in Neoplasia

  • Chi V. Dang
  • Linda A. Lee

Part of the Medical Intelligence Unit book series (MIU.LANDES)

Table of contents

  1. Front Matter
    Pages N2-IX
  2. Chi V. Dang, Linda A. Lee
    Pages 1-36
  3. Chi V. Dang, Linda A. Lee
    Pages 37-64
  4. Chi V. Dang, Linda A. Lee
    Pages 65-71
  5. Chi V. Dang, Linda A. Lee
    Pages 73-84
  6. Chi V. Dang, Linda A. Lee
    Pages 85-107
  7. Chi V. Dang, Linda A. Lee
    Pages 109-118
  8. Chi V. Dang, Linda A. Lee
    Pages 119-149
  9. Chi V. Dang, Linda A. Lee
    Pages 151-163
  10. Chi V. Dang, Linda A. Lee
    Pages 165-170
  11. Back Matter
    Pages 193-201

About this book

Introduction

1. 1 SCOPE OF BOOK n explosion of novel findings in the past decade has contrib­ A uted to the great progress toward understanding the biology of human cancers. Much of this progress can be attributed to our abil­ ity to dissect many biological processes at the molecular level. Most spectacular is the technology of molecular biology that allows identi­ fication and characterization of genes that participate in the genesis of human cancers. Three major groups of genes appear to play out the drama of cancer development: tumor suppressor genes, mis­ match repair genes, and oncogenes. The tumor suppressor genes 1 encode products that are inhibitory to cell proliferation. The loss of these inhibitors, by mutation or deletion, can unleash cells from their restraints to proliferate. Mutations in the mismatch repair 2 10 genes also have been implicated in tumorigenesis. - The inability of cells to repair spontaneously occurring mutations leads to genom­ ic instability and could potentially result in the accumulation of car­ cinogenic DNA lesions. Finally, activation of proto-oncogenes, which are normal cellular genes, into oncogenes could accelerate the 11 processes of cell proliferation. c-myc was one of the very first proto­ oncogenes to be identified and because it normally plays pivotal roles in both cell proliferation and cell death has enticed many to investigate the molecular mechanisms by which it transforms cells.

Keywords

biology cancer cell cell death gene oncogene programmed cell death proliferation protein signal transduction transcription tumor viruses

Authors and affiliations

  • Chi V. Dang
    • 1
  • Linda A. Lee
    • 1
  1. 1.School of MedicineThe Johns Hopkins UniversityBaltimoreUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-22681-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 1995
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-662-22683-4
  • Online ISBN 978-3-662-22681-0
  • Series Print ISSN 1080-3645
  • Buy this book on publisher's site
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