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p53 Suppressor Gene

  • Tapas Mukhopadhyay
  • Steven A. Maxwell
  • Jack A. Roth

Part of the Molecular Biology Intelligence Unit book series (MBIU)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Tapas Mukhopadhyay, Steven A. Maxwell, Jack A. Roth
    Pages 1-11
  3. Tapas Mukhopadhyay, Steven A. Maxwell, Jack A. Roth
    Pages 13-18
  4. Tapas Mukhopadhyay, Steven A. Maxwell, Jack A. Roth
    Pages 19-54
  5. Tapas Mukhopadhyay, Steven A. Maxwell, Jack A. Roth
    Pages 55-72
  6. Tapas Mukhopadhyay, Steven A. Maxwell, Jack A. Roth
    Pages 73-112
  7. Tapas Mukhopadhyay, Steven A. Maxwell, Jack A. Roth
    Pages 113-125
  8. Back Matter
    Pages 127-133

About this book

Introduction

This book is about the p53 gene, one of the most frequently mutated or deleted genes in human cancers. The frequent occurrence of inactivated p53 implicates this gene product in the genesis of many human cancers. The p53 gene can suppress the growth of cancer cells and the transformation process by oncogenes. The p53 protein is a transcription factor that can repress or activate promoters containing one of three p53 DNA-binding motifs. The activity of p53 is regulated by phosphorylation and other transcription factors. Replacement of the p53 function or restoration of the p53 biochemical pathway is a focus of gene therapy.

Keywords

Promoter cancer gene therapy genes oncogene oncogenes oncology p53 protein protooncogenes regulation transcription tumor tumor suppressors

Authors and affiliations

  • Tapas Mukhopadhyay
    • 1
  • Steven A. Maxwell
    • 1
  • Jack A. Roth
    • 1
  1. 1.M. D. Anderson Cancer CenterUniversity of TexasHoustonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-22275-1
  • Copyright Information Springer-Verlag Berlin Heidelberg 1995
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-662-22277-5
  • Online ISBN 978-3-662-22275-1
  • Series Print ISSN 1431-0414
  • Buy this book on publisher's site
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