The Biology of Germinal Centers in Lymphoid Tissue

  • G. Jeanette Thorbecke
  • Vincent K. Tsiagbe

Table of contents

  1. Front Matter
    Pages i-xi
  2. J. G. Tew, D. Qin, J. Wu, G. F. Burton, A. K. Szakal
    Pages 105-129
  3. R. A. Insel, M. H. Nahm
    Pages 131-164
  4. V. K. Tsiagbe, N. M. Ponzio, G. S. Erianne, D. J. Zhang, G. J. Thorbecke, G. Inghirami
    Pages 199-234
  5. Back Matter
    Pages 235-241

About this book


This book meets the demand of a recent surge of interest in germinal centers, the foci of antigen-induced, rapidly proliferating B lymphocytes, representing sites in mammalian lymphoid tissue where memory B cells are generated. Various aspects of the generation of germinal centers, the somatic hypermutation process and the cellular interactions involved in the selection process are discussed in detail. A chapter on germinal center-derived lymphomas completes the treatment.


Antigen B lymphocytes Lymphozyten biology cell development genes immunoglobulin influence lymphocytes lymphoid tissue lymphoma mutation retroviruses tissue

Authors and affiliations

  • G. Jeanette Thorbecke
    • 1
  • Vincent K. Tsiagbe
    • 1
  1. 1.Department of PathologyNew York University Medical Center and Kaplan Comprehensive Cancer CenterNew YorkUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1998
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-662-13143-5
  • Online ISBN 978-3-662-13141-1
  • Buy this book on publisher's site
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