© 2001

Purinergic and Pyrimidinergic Signalling I

Molecular, Nervous and Urogenitary System Function

  • Maria Pia Abbracchio
  • Michael Williams

Part of the Purinergic and Pyrimidinergic Signalling book series (HEP, volume 151 / 1)

Table of contents

  1. Front Matter
    Pages I-XXX
  2. Purinergic Neurotransmission: An Historical Background

    1. M. P. Abbracchio, M. Williams
      Pages 1-16
  3. Receptor Classification

    1. Front Matter
      Pages 17-17
    2. A. Lorenzen, U. Schwabe
      Pages 19-45
    3. I. P. Chessell, A. D. Michel, P. P. A. Humphrey
      Pages 47-63
    4. M. R. Boarder, T. E. Webb
      Pages 65-88
    5. G. Burnstock
      Pages 89-127
    6. K. A. Jacobson, L. J. S. Knutsen
      Pages 129-175
  4. Neurotransmission

    1. Front Matter
      Pages 177-177
    2. B. Sperlágh, E. S. Vizi
      Pages 179-208
    3. H. Zimmermann
      Pages 209-250
    4. S. A. Masino, T. V. Dunwiddie
      Pages 251-288
    5. J. T. Neary, M. P. Abbracchio
      Pages 305-338
    6. M. W. Salter, A. Sollevi
      Pages 371-401
  5. Back Matter
    Pages 517-526

About this book


Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.


Nervous System New Therapeutic entities Pathophysiologie Purine Purines Pyrimidine Pyrimidines Regulation adenosine pathophysiology physiology receptor signaling signaling system tissue

Editors and affiliations

  • Maria Pia Abbracchio
    • 1
  • Michael Williams
    • 2
  1. 1.Institute of Pharmacological SciencesUniversity of MilanMilanItaly
  2. 2.Department of Molecular Pharmacology and Biological ChemistryNorthwestern University Medical SchoolChicagoUSA

Bibliographic information

  • Book Title Purinergic and Pyrimidinergic Signalling I
  • Book Subtitle Molecular, Nervous and Urogenitary System Function
  • Editors Maria P. Abracchio
    Michael Williams
  • Series Title Purinergic and Pyrimidinergic Signalling
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2001
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-67849-6
  • Softcover ISBN 978-3-642-08742-4
  • eBook ISBN 978-3-662-09604-8
  • Series ISSN 0171-2004
  • Series E-ISSN 1865-0325
  • Edition Number 1
  • Number of Pages XXX, 526
  • Number of Illustrations 31 b/w illustrations, 0 illustrations in colour
  • Topics Pharmacology/Toxicology
    Human Physiology
    Cell Biology
  • Buy this book on publisher's site
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