© 2002

Pathogenicity Islands and the Evolution of Pathogenic Microbes

Volume I

  • Jörg Hacker
  • James B. Kaper

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 264/1)

Table of contents

  1. Front Matter
    Pages I-XVII
  2. W. Arber
    Pages 1-14
  3. A. G. Torres, J. B. Kaper
    Pages 31-48
  4. M. Ingersoll, E. A. Groisman, A. Zychlinsky
    Pages 49-65
  5. R. A. Kingsley, A. J. Bäumler
    Pages 67-87
  6. P. P. Reeves, L. Wang
    Pages 109-135
  7. B. Barrett, L. Ebah, I. S. Roberts
    Pages 137-155
  8. U. Dobrindt, U. Hentschel, J. B. Kaper, J. Hacker
    Pages 157-175
  9. F. von Wintzingerode, G. Gerlach, B. Schneider, R. Gross
    Pages 177-199
  10. K. Larbig, C. Kiewitz, B. Tümmler
    Pages 201-211
  11. Back Matter
    Pages 213-234

About this book


It has been known for a number of years that not only pathogenicity islands but also plasmids and bacteriophages are able to carry genes whose products are involved in pathogenic processes. Accordingly, such elements and their products play an important role in pathogenesis due to the intestinal E. coli as well due to Shigellae. Another interesting aspect which is reflected in different articles is that genomes evolve by acquisition of new pieces of DNA following gene transfer, but also by genome reduction. Different mechanisms include the deletion of sequences or the elimination of functions by the accumulation of point mutations or rearrangements.


DNA Escherichia coli bacteria bordetella enterobacteria gene transfer genes microbe pathogenesis pseudomonas shigella yersinia

Editors and affiliations

  • Jörg Hacker
    • 1
  • James B. Kaper
    • 2
  1. 1.Institut für Molekulare InfektionsbiologieUniversität WürzburgWürzburgGermany
  2. 2.Center for Vaccine DevelopmentUniversity of Maryland School of MedicineBaltimoreUSA

Bibliographic information

  • Book Title Pathogenicity Islands and the Evolution of Pathogenic Microbes
  • Book Subtitle Volume I
  • Editors J. Hacker
    J.B. Kaper
  • Series Title Current Topics in Microbiology and Immunology
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2002
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-42681-3
  • Softcover ISBN 978-3-642-07656-5
  • eBook ISBN 978-3-662-09217-0
  • Series ISSN 0070-217X
  • Edition Number 1
  • Number of Pages XVII, 234
  • Number of Illustrations 23 b/w illustrations, 0 illustrations in colour
  • Topics Microbiology
    Human Genetics
  • Buy this book on publisher's site
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From the reviews:

"In addition to classic mutational events, a highly successful strategy of generating genetic diversity in bacteria is the acquisition of genomic islands. … This compendium … features an international assembly of authors including W. Arber (Basel) giving a lucid introduction into the evolution of prokaryotic genomes. The two-volume work provides a comprehensive overview of the current state of knowledge on PAIs and other mobile virulence determinants in bacterial as well as fungal pathogens of humans and plants." (Susanne Rohrer, BioWorld, Issue 6, 2002)