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New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy

  • Conference proceedings
  • © 2004

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Editors:
  1. K. S. Korach
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  2. A. Hillisch
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  3. K. H. Fritzemeier
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Part of the book series: Ernst Schering Foundation Symposium Proceedings (SCHERING FOUND, volume 46)

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Table of contents (13 papers)

  1. Front Matter

    Pages I-XVI
    Download chapter PDF

  2. Estrogens: From Classical Endocrine Action to Tissue Selective Action

    • C. R. Lyttle, B. S. Komm, B. J. Cheskis
    Pages 1-21

  3. Identification of RIP140 as a Nuclear Receptor Cofactor with a Role in Female Reproduction

    • M. Parker, R. White, G. Leonardsson, S. Milligan, J. Steel
    Pages 23-31

  4. A Structural Explanation for ERα/ERβ SERM Discrimination

    • G. L. Greene, A. K. Shiau, K. W. Nettles
    Pages 33-45

  5. Protein Structure-Based Design, Synthesis Strategy and In Vitro Pharmacological Characterization of Estrogen Receptor α and β Selective Compounds

    • A. Hillisch, O. Peters, D. Kosemund, G. Müller, A. Walter, W. Elger et al.
    Pages 47-62

  6. How to Understand Estrogen Signaling from the Phenotypes of ERα and ERβ Knockout Mice

    • M. Warner, J.-Ã…. Gustafsson
    Pages 63-77

  7. Mechanisms of Estrogenic Effects on Neurobiological Functions

    • D. W. Pfaff
    Pages 79-88

  8. Role of Estrogens in the Male Reproductive Tract

    • E. R. Simpson, S. McPherson, M. Jones, K. Robertson, W. C. Boon, G. Risbridger
    Pages 89-112

  9. Are Estrogens of Importance to Ovarian Function?

    • S. G. Hillier
    Pages 113-125

  10. Biological Effects of ERα-and ERβ-Selective Estrogens

    • K.-H. Fritzemeier, A. Hillisch, W. Elger, U. Kaufmann, U. Kollenkirchen, D. Kosemund et al.
    Pages 127-150

  11. The ERE-luc Reporter Mouse

    • P. Ciana, P. Mussi, M. Raviscioni, A. Biserni, L. Ottobrini, E. Vegeto et al.
    Pages 151-168

  12. Role of Estrogens in Ovarian Dysfunction and Fertility. Options for New Therapies with SERMs

    • B. C. J. M. Fauser, J. S. E. Laven
    Pages 169-179

  13. Estrogens and Atherosclerosis

    • F. Bayard, P. Gourdy, R. Elhage, L. Brouchet, B. Garmy-Susini, C. Castano et al.
    Pages 181-187

  14. Hormone Replacement (Therapy): A Time for Interrogation, Information and Further Studies

    • O. Markowitz, C. Meynant, P. Bouchard
    Pages 189-209

  15. Back Matter

    Pages 211-214
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Keywords

About this book

From our current knowledge, it is obvious that estrogen action in­ volves more than reproduction and fertility. Rather, estrogens affect and influence a number of other organ systems such as the immune, cardiovascular and central nervous system as well as the gastrointes­ tinal tract, urinary tract and skeleton. The importance of estrogens and estrogen receptor activity is appreciated from the spectrum of significant physiological dysfunctions that occur when there is a loss The participants of the workshop VI Preface of the hormone or the receptor activity. Loss of estrogen, however (for instance during menopause), occurs with time and results in a variety of clinical conditions. We know that the developmental loss of estrogen, as seen in clinical cases of aromatase gene mutations and experimental models, has dramatic effects in both men and women alike. The evidence that these effects are mediated through the estrogen receptor(s) is based on similar but not always identical phenotypes as observed in experimental animal models of estrogen receptor mutations as well as the single clinical case of an estrogen receptor alpha mutant patient. Developing an understanding of the spectrum of estrogen in a variety of tissues related to the condition of estrogen loss is a major and highly active clinical as well as basic scientific research area. Following the discovery of a second estrogen receptor and possible receptor ligand-independent activity as well as the genomic and non­ genomic actions of estrogen, it is clear that the mechanisms of the effects of estrogen are multifaceted.

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