© 2002

Clinical and Diagnostic Pathology of Graft-versus-Host Disease

  • Concise description of the clinical pathology of Graft-versus-Host Disease

  • Instructive guide to the histological diagnosis

  • Differential diagnostic problems and potential diagnostic pitfalls

  • Detailed description of applicability and limits of immunohistological methods in the diagnosis of this disease


Table of contents

  1. Front Matter
    Pages I-XVI
  2. Berno Heymer
    Pages 1-3
  3. Berno Heymer
    Pages 5-11
  4. Berno Heymer
    Pages 13-26
  5. Berno Heymer
    Pages 27-40
  6. Berno Heymer
    Pages 103-121
  7. Berno Heymer
    Pages 123-125
  8. Berno Heymer
    Pages 127-128
  9. Back Matter
    Pages 129-156

About this book


Graft-versus-host Disease (GvHD) occurs primarily but not exclusively as a complication in the context of allogeneic bone marrow or peripheral blood stem cell transplantation (BMT or PBSCT), the treatment of choice for various life-threatening diseases. GvHD may affect skin, liver, gut, and other organs and sometimes runs a devastating or even lethal course. The diagnosis of GvHD is based on both clinical and histomorphological parameters. However, due to the widespread use of GvHD prophylaxis in patients undergoing allogeneic BMT or PBSCT, the number of histologically typical lesions has decreased, while the number of atypical, low-grade or masked lesions has increased. Therefore, an update of the clinical and diagnostic pathology of GvHD of skin, liver, gastrointestinal tract and other organs is required. In the present volume the histological features of GvHD lesions under today's conditions are described and illustrated in detail. Particular emphasis is placed on differential diagnostic problems and histodiagnostic pitfalls. Finally, the applicability and limits of immunohistological methods for the diagnosis of GvHD are shown.


Alloimmune Reacation Bone Marrow Transplantation Fatigue Graft-versus-Host Disease Hematology Hematopathology Hematopoietic Stem Cell Stem Cell Transplantation

Authors and affiliations

  1. 1.Abteilung PathologieUniversität UlmUlmGermany

Bibliographic information

  • Book Title Clinical and Diagnostic Pathology of Graft-versus-Host Disease
  • Authors Berno Heymer
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2002
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-67719-2
  • Softcover ISBN 978-3-642-08721-9
  • eBook ISBN 978-3-662-04715-6
  • Edition Number 1
  • Number of Pages XVI, 156
  • Number of Illustrations 1 b/w illustrations, 78 illustrations in colour
  • Topics Pathology
    Transplant Surgery
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals


From the reviews:

"This is an excellent, well illustrated book for pathologists and oncologists alike. The author's hard work has resulted in an outstanding book."  Review from Doody's Notes

"The textbook provides the reader with information, which can be easily transformed into the daily work of a routine pathologist. … The needed grading and image findings indicative for the development are well described and demonstrated by color plates. … The references are extensive, and well selected." (Klaus Kayser, Electronic Journal of Pathology and Histology, Vol. 8 (3), 2002)