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© 1999

Therapeutic Angiogenesis

  • Editors
  • J. A. Dormandy
  • W. P. Dole
  • G. M. Rubanyi
  • First book on Therapeutic Angiogenesis

  • First book on Angiogenic Gene Therapy

  • First book to review better basic science and clinical applications of Therapeutic Angiogenesis

Conference proceedings

Part of the Ernst Schering Research Foundation Workshop 28 book series (SCHERING FOUND, volume 28)

Table of contents

  1. Front Matter
    Pages I-XI
  2. K. S. Riddelle-Spencer, D. A. Cheresh
    Pages 23-39
  3. E. Deindl, W. Schaper
    Pages 67-86
  4. O. Hudlická, M. D. Brown
    Pages 87-123
  5. S. F. Aranki, F. Mannting, S. K. Shernan, N. C. Cummings, S. P. Sears, L. H. Cohn
    Pages 163-173
  6. Back Matter
    Pages 183-186

About these proceedings

Introduction

Over the past decade, rapid progress had been made in elucidating the cellular and molecular mechanisms of new blood vessel formation in both health and disease. Lack of sufficient angiogenesis (new capillary development) and collateral formation (remodeling of existing blood vessels) in adult tissues (e. g. , heart, brain, skeletal muscle) during criti­ cal ischemia has prompted novel therapeutic strategies to stimulate/fa­ cilitate angiogenesis and collateral formation in ischemic conditions ("therapeutic angiogenesis"). Therapeutic angiogenesis describes a strategy of inducing new col­ lateral vessels that can bypass vascular obstructions caused by atherosclerotic disease and stimulating new capillaries that can en­ hance tissue oxygen exchange. Naturally occurring growth factors (e. g. , FGFs, VEGFs) have been identified and demonstrated to induce new blood vessel formation in the adult organism. The therapeutic ap­ plication of these growth factors has been demonstrated to enhance these natural processes and have been shown in a number of animal models to increase blood flow and oxygen exchange to ischemic tis­ sues. Therapeutic angiogenesis therefore represents a new medical principle that is anticipated to be used as an adjunct or alternative to angioplasty and/or bypass surgery. A number of strategies have been proposed and tested to deliver growth factors. One strategy is the direct administration of the growth factor protein by intramuscular, intraarte­ rial or intravenous delivery.

Keywords

Angiogenic Growth Factors Protein Therapy Transmyocardial Laser angiogenesis artery cardiovascular coronary artery disease coronary heart disease gene therapy heart

Bibliographic information

  • Book Title Therapeutic Angiogenesis
  • Editors J.A. Dormandy
    W.P. Dole
    G.M. Rubanyi
  • Series Title Ernst Schering Research Foundation Workshop 28
  • DOI https://doi.org/10.1007/978-3-662-03776-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 1999
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-65693-7
  • Softcover ISBN 978-3-662-03778-2
  • eBook ISBN 978-3-662-03776-8
  • Series ISSN 0947-6075
  • Edition Number 1
  • Number of Pages XI, 186
  • Number of Illustrations 21 b/w illustrations, 0 illustrations in colour
  • Topics Cardiology
    Angiology
  • Buy this book on publisher's site
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